{"id":"W2121550854","doi":"10.1093/jac/dkv060","title":"Multiple mutations and increased RNA expression in tetracycline-resistant <i>Streptococcus pneumoniae</i> as determined by genome-wide DNA and mRNA sequencing","year":2015,"lang":"en","type":"article","venue":"Journal of Antimicrobial Chemotherapy","topic":"Pneumonia and Respiratory Infections","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier de l'Université Laval","funders":"Canadian Institutes of Health Research; McGill University","keywords":"Biology; Tetracycline; Gene; Genetics; Mutant; Coding region; Molecular biology; 23S ribosomal RNA; Microbiology; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001448082,0.000284317,0.0003139132,0.0004425208,0.0001645127,0.0003956295,0.0001376418,0.0003891384,0.0008042514],"category_scores_gemma":[0.0002370792,0.0002120594,0.0003607143,0.0003796309,0.0001725679,0.0001008945,0.0001837669,0.000326516,0.0003635578],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002141724,"about_ca_system_score_gemma":0.0001365029,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001082942,"about_ca_topic_score_gemma":0.001644831,"domain_scores_codex":[0.9997433,0.00001651567,0.0000168048,0.0001021682,0.00008827213,0.0000328823],"domain_scores_gemma":[0.9997397,0.0000368177,0.0001398023,0.00001866311,0.000039953,0.0000251366],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00008720114,0.000005990359,0.002309541,0.00004739073,0.00001062425,0.00004926512,0.00001689669,0.00004348436,0.9961839,0.00001051433,0.00003282666,0.001202394],"study_design_scores_gemma":[0.00001461997,0.0003991066,0.4004479,0.00003845903,0.0001186448,0.001582724,0.0001710163,0.002093825,0.5908895,0.00007566922,0.004142582,0.00002596819],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922868,0.00116846,0.002510229,0.00005273262,0.00001305702,0.0000168847,0.003267323,0.0001145806,0.0005700109],"genre_scores_gemma":[0.9832349,0.0009990823,0.008091182,0.0001056046,0.00001549215,0.00005372135,0.005280175,0.00006808576,0.002151751],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001082942,"threshold_uncertainty_score":0.002690494,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01411082483919364,"score_gpt":0.2592507045343843,"score_spread":0.2451398796951907,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}