{"id":"W2121558572","doi":"10.1111/pbi.12416","title":"Regulatory approval and a first‐in‐human phase I clinical trial of a monoclonal antibody produced in transgenic tobacco plants","year":2015,"lang":"en","type":"article","venue":"Plant Biotechnology Journal","topic":"Transgenic Plants and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":263,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"European Commission; Wellcome Trust; Wellcome","keywords":"Biology; Monoclonal antibody; Transgene; Genetically modified crops; Biotechnology; Virology; Computational biology; Antibody; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007094527,0.000763468,0.0009055117,0.000348692,0.0007936561,0.001378896,0.001030584,0.004797848,0.006638024],"category_scores_gemma":[0.003151821,0.0004214353,0.001777607,0.0004156201,0.001081387,0.0006152144,0.0005069516,0.004289774,0.002247589],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00130428,"about_ca_system_score_gemma":0.003270146,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006833939,"about_ca_topic_score_gemma":0.001545284,"domain_scores_codex":[0.996941,0.001519987,0.0001245189,0.0002932803,0.0007180719,0.0004030647],"domain_scores_gemma":[0.9980709,0.0003664595,0.0003051065,0.0003204431,0.0004983848,0.0004387752],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.08809888,0.01621662,0.003212789,0.004420856,0.001051028,0.002670047,0.001213266,0.002407227,0.4403949,0.0169348,0.1233304,0.3000492],"study_design_scores_gemma":[0.06570686,0.1815205,0.01116366,0.001481193,0.0009545577,0.003565063,0.0003128346,0.003471683,0.1187168,0.004080991,0.6089091,0.0001167608],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6098588,0.02409333,0.0778783,0.03088544,0.007411621,0.0996769,0.02004124,0.003050428,0.1271041],"genre_scores_gemma":[0.7849138,0.01446494,0.04431147,0.0263679,0.001244552,0.05445764,0.01679012,0.0004391533,0.05701036],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007094527,"threshold_uncertainty_score":0.03751993,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05428760123573823,"score_gpt":0.3542650523487229,"score_spread":0.2999774511129846,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}