{"id":"W2121592758","doi":"10.1124/jpet.103.054072","title":"Novel Functional Polymorphisms in the UGT1A7 and UGT1A9 Glucuronidating Enzymes in Caucasian and African-American Subjects and Their Impact on the Metabolism of 7-Ethyl-10-hydroxycamptothecin and Flavopiridol Anticancer Drugs","year":2003,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":184,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"","keywords":"Glucuronidation; Single-nucleotide polymorphism; Biology; Genetics; Gene; Irinotecan; Allele; Missense mutation; Molecular biology; Mutation; Cancer; Genotype; In vitro; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005752491,0.0001998643,0.0002837793,0.00008462137,0.00009499687,0.00002577692,0.00008028519,0.00007203412,0.00002073176],"category_scores_gemma":[0.000007274733,0.0001135971,0.00004434511,0.00009430297,0.0004321426,0.00001367556,0.00004343709,0.0002120618,4.38867e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002012861,"about_ca_system_score_gemma":0.00007330785,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004279965,"about_ca_topic_score_gemma":0.00001435174,"domain_scores_codex":[0.9990338,0.0002106892,0.000265073,0.0001859799,0.0001036056,0.000200857],"domain_scores_gemma":[0.999469,0.0001549918,0.0002151254,0.00007831311,0.00002656923,0.00005594001],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006649187,0.0001484931,0.0009300562,0.000005382234,0.0001781791,0.000002182983,0.003329596,0.00001100853,0.9918292,0.000652445,0.00002416677,0.002224443],"study_design_scores_gemma":[0.002752342,0.001141968,0.006046975,0.00001822277,0.00006941103,0.0002618265,0.006732456,0.0001303747,0.9801382,0.0002832421,0.002259919,0.0001650635],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9742091,0.02446621,0.00004700445,0.0009155991,0.0001074056,0.0001678222,0.00001268904,0.000001003106,0.00007317563],"genre_scores_gemma":[0.9942955,0.003427017,0.00007936616,0.002070502,0.00008936878,0.000009589977,0.000001128696,0.00001435431,0.00001318869],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0210392,"threshold_uncertainty_score":0.4632356,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01867245517958496,"score_gpt":0.3060705766953062,"score_spread":0.2873981215157212,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}