{"id":"W2121592758","doi":"10.1124/jpet.103.054072","title":"Novel Functional Polymorphisms in the UGT1A7 and UGT1A9 Glucuronidating Enzymes in Caucasian and African-American Subjects and Their Impact on the Metabolism of 7-Ethyl-10-hydroxycamptothecin and Flavopiridol Anticancer Drugs","year":2003,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":184,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"","keywords":"Glucuronidation; Single-nucleotide polymorphism; Biology; Genetics; Gene; Irinotecan; Allele; Missense mutation; Molecular biology; Mutation; Cancer; Genotype; In vitro; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000350386,0.0007186247,0.000505726,0.0008345708,0.0005198526,0.0003739211,0.0002571903,0.0008246927,0.002637142],"category_scores_gemma":[0.001139857,0.0003299482,0.0005012684,0.0007782981,0.0004451,0.0002316111,0.0001610423,0.0006769581,0.000208897],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002225186,"about_ca_system_score_gemma":0.0002075482,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003762181,"about_ca_topic_score_gemma":0.002193749,"domain_scores_codex":[0.9996575,0.0001216737,0.00003215492,0.00009120091,0.00004515935,0.00005230514],"domain_scores_gemma":[0.9993018,0.0003097335,0.0001576189,0.00003542891,0.00004114131,0.0001543034],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01046428,0.000711481,0.9262894,0.00006017416,0.0006559532,0.008801376,0.001032237,0.0003936928,0.04141423,0.0007099756,0.0004629232,0.009004168],"study_design_scores_gemma":[0.0001620051,0.0008447974,0.9880702,0.00001038379,0.0003284486,0.007109811,0.0002527282,0.0007133051,0.001820603,0.0002261475,0.0004447814,0.00001669812],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993578,0.0001587353,0.00008752829,0.00004227432,0.000007798632,0.000004853821,0.0001031039,0.000003763957,0.0002341992],"genre_scores_gemma":[0.9994235,0.00007101518,0.000108652,0.00002733392,0.00001550782,0.000006059782,0.00008971879,0.000004739733,0.0002535838],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003762181,"threshold_uncertainty_score":0.008822143,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01867245517958496,"score_gpt":0.3060705766953062,"score_spread":0.2873981215157212,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}