{"id":"W2121647317","doi":"10.1128/aac.44.3.720-726.2000","title":"Enzymes Catalyzing the Early Steps of Clavulanic Acid Biosynthesis Are Encoded by Two Sets of Paralogous Genes in <i>Streptomyces clavuligerus</i>","year":2000,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Directorate for Biological Sciences","keywords":"Streptomyces clavuligerus; ORFS; Clavulanic acid; Biology; Biochemistry; Gene; Biosynthesis; Mutant; Amino acid; Shikimic acid; Open reading frame; Genetics; Peptide sequence","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007497652,0.000734548,0.0003473855,0.0004919234,0.0002250195,0.0004520174,0.0002141775,0.0002264637,0.0006659364],"category_scores_gemma":[0.0002879669,0.0001830734,0.0003803924,0.0003507591,0.0002860326,0.0001649268,0.0004515529,0.0004008537,0.0005576842],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003656517,"about_ca_system_score_gemma":0.0003716856,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001496192,"about_ca_topic_score_gemma":0.001156605,"domain_scores_codex":[0.9998121,0.00001474593,0.00001647701,0.00005337855,0.00006060951,0.00004275439],"domain_scores_gemma":[0.9996375,0.00003805356,0.0001362808,0.00003902447,0.00003619863,0.0001128185],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001798104,0.00003609981,0.00391182,0.00003708061,0.000007871372,0.0001906748,0.00004678702,0.0001762463,0.9890004,0.0001281371,0.00004581767,0.006239212],"study_design_scores_gemma":[0.00003834749,0.0005904663,0.1460341,0.00002531957,0.00006055191,0.002178326,0.0002572285,0.002554677,0.8432096,0.0003428253,0.004675269,0.00003345889],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925607,0.0004439329,0.004944334,0.00003664256,0.00001813444,0.00003403302,0.0006568177,0.0002052885,0.001100131],"genre_scores_gemma":[0.9867534,0.0002052553,0.006333508,0.00002873665,0.000008563104,0.00003737479,0.004534552,0.00003682919,0.002061649],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001496192,"threshold_uncertainty_score":0.002974987,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009541346848087787,"score_gpt":0.2445088987909,"score_spread":0.2349675519428122,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}