{"id":"W2121650311","doi":"10.1002/ijc.29081","title":"Retinoic acid signaling in cancer: The parable of acute promyelocytic leukemia","year":2014,"lang":"en","type":"review","venue":"International Journal of Cancer","topic":"Retinoids in leukemia and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Cancer Research; European Research Council; Institut National Du Cancer; Université Paris Diderot; Institut Universitaire de France; Centre National de la Recherche Scientifique; Ligue Contre le Cancer; Fondation ARC pour la Recherche sur le Cancer; Institut National de la Santé et de la Recherche Médicale","keywords":"Acute promyelocytic leukemia; Retinoic acid; Cancer research; Leukemia; Retinoic acid receptor alpha; Chromosomal translocation; Retinoic acid receptor; Cancer; Promyelocytic leukemia protein; Biology; Retinoic acid-inducible orphan G protein-coupled receptor; Disease; Medicine; Bioinformatics; Immunology; Genetics; Internal medicine; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004994938,0.0002416723,0.0007465606,0.0001299826,0.00002453049,0.00003466428,0.001120077,0.0002429814,0.00007156758],"category_scores_gemma":[0.00008392498,0.0001556653,0.0004385659,0.0001271648,0.0001081651,0.000008417924,0.0001096241,0.0004320244,0.000001821675],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003826626,"about_ca_system_score_gemma":0.002399136,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005881317,"about_ca_topic_score_gemma":0.00002355678,"domain_scores_codex":[0.9980488,0.0001353117,0.0009617527,0.0002117061,0.0004621836,0.0001802809],"domain_scores_gemma":[0.9976957,0.00004521486,0.001490804,0.0001982035,0.0005244222,0.00004569216],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000283566,0.00006102882,0.0003273973,0.004321471,0.004454257,0.00008381552,0.0001138698,0.001197376,0.01532594,0.00008548438,0.003580437,0.9701654],"study_design_scores_gemma":[0.0004822153,0.0001091971,0.000005874467,0.008085532,0.0006582353,0.0001477397,0.00001056979,0.00001549911,0.02783197,0.00008381411,0.9623718,0.0001975233],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003685836,0.994571,0.0001817248,0.00008885958,0.001007689,0.0001624672,0.00003950595,0.000001631654,0.0002613042],"genre_scores_gemma":[0.01496613,0.9829632,0.00008876582,0.0000828846,0.001404811,0.00005811302,0.00002554516,0.00003349138,0.0003770389],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9699678,"threshold_uncertainty_score":0.6347849,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01906539997965422,"score_gpt":0.3601236971132359,"score_spread":0.3410582971335817,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}