{"id":"W2121660436","doi":"10.1161/hh0102.102977","title":"Expression and Intracellular Localization of an <b> <i>SCN5A</i> </b> Double Mutant R1232W/T1620M Implicated in Brugada Syndrome","year":2002,"lang":"en","type":"article","venue":"Circulation Research","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":177,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"","keywords":"Mutant; Brugada syndrome; Sodium channel; Cell biology; Wild type; Potassium channel; Endoplasmic reticulum; Molecular biology; Biology; Internal medicine; Medicine; Endocrinology; Chemistry; Sodium; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009651071,0.0002971369,0.0002170764,0.0001624643,0.0001324153,0.0002171544,0.0002037673,0.00040417,0.0008625367],"category_scores_gemma":[0.00009855894,0.0001322905,0.0002488571,0.0001070714,0.0002325513,0.0001337864,0.0001607255,0.0002615497,0.0005946567],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002164834,"about_ca_system_score_gemma":0.0001115203,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007630472,"about_ca_topic_score_gemma":0.000664259,"domain_scores_codex":[0.9998906,0.00001483463,0.00001739583,0.00002720555,0.00002996809,0.00002001943],"domain_scores_gemma":[0.9998553,0.00001482207,0.00005606224,0.00001086554,0.000009119777,0.00005377322],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002592394,0.000002920343,0.0001258078,0.000006254048,0.00000202894,0.0001405874,0.000006765618,0.00001528204,0.9995415,0.00001509223,0.000007644329,0.0001101484],"study_design_scores_gemma":[0.00004750179,0.0003289212,0.02675984,0.00001054361,0.0000364733,0.005355237,0.0001308162,0.001803456,0.9634487,0.00008579604,0.00197767,0.00001502237],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982237,0.0002570668,0.0008195376,0.00003917537,0.00001614452,0.000004582593,0.0001813797,0.00002585453,0.0004325623],"genre_scores_gemma":[0.9974299,0.0002129174,0.001047135,0.00003184531,0.000007775086,0.00000905905,0.0004208244,0.0000267874,0.0008137804],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008625367,"threshold_uncertainty_score":0.002885461,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04515373411034981,"score_gpt":0.3260871480506824,"score_spread":0.2809334139403326,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}