{"id":"W2121713269","doi":"10.1523/jneurosci.2361-07.2007","title":"Immunotherapy Targeting Pathological Tau Conformers in a Tangle Mouse Model Reduces Brain Pathology with Associated Functional Improvements","year":2007,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":506,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; School of Medicine, New York University; York University; National Institute on Aging; King's College London; Alzheimer's Association","keywords":"Immunogen; Tauopathy; Tau protein; Tangle; Pathology; Epitope; Frontotemporal dementia; Immunotherapy; Antibody; Neuroscience; Pathological; Alzheimer's disease; Biology; Immunology; Dementia; Medicine; Neurodegeneration; Disease; Monoclonal antibody; Immune system","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03822067284850015,"score_gpt":0.321082345148119,"score_spread":0.2828616722996188,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}