{"id":"W2121752736","doi":"10.1196/annals.1346.044","title":"Misconceptions About Calcimimetics","year":2006,"lang":"en","type":"review","venue":"Annals of the New York Academy of Sciences","topic":"Parathyroid Disorders and Treatments","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"College of Physicians and Surgeons of Ontario; Toronto Public Health","funders":"","keywords":"Cinacalcet; Calcimimetic; Calcium-sensing receptor; Allosteric modulator; Allosteric regulation; Chemistry; Drug discovery; Parathyroid hormone; Hyperparathyroidism; Pharmacology; Receptor; Secondary hyperparathyroidism; Calcium; Medicine; Endocrinology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003427357,0.0009643468,0.001372066,0.004171334,0.0007324297,0.002491609,0.001781152,0.003304823,0.005507241],"category_scores_gemma":[0.009233314,0.0004686478,0.0007029852,0.004700007,0.004397828,0.00719669,0.001765804,0.005433974,0.004269487],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002011901,"about_ca_system_score_gemma":0.001706598,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001573638,"about_ca_topic_score_gemma":0.002364345,"domain_scores_codex":[0.9981523,0.0005213176,0.0002749206,0.0002646208,0.0007053777,0.00008153963],"domain_scores_gemma":[0.9931927,0.005118926,0.0005310165,0.0001818612,0.0007963477,0.0001791513],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009792981,0.00004403816,0.0003903834,0.01514949,0.000119938,0.001210206,0.001016984,0.0004472772,0.0009456811,0.02983051,0.2010798,0.7496677],"study_design_scores_gemma":[0.0000086108,0.00001787437,0.0002670227,0.005322306,0.00002815661,0.002627633,0.0002555973,0.00002886691,0.0001628863,0.007718021,0.9835463,0.00001683679],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001240767,0.9869531,0.0001719532,0.007422326,0.002060445,0.00000303274,0.00001838549,0.00001425839,0.003232399],"genre_scores_gemma":[0.001693439,0.9823967,0.000247873,0.01149174,0.002645863,0.000009064033,0.00002600025,0.000005944797,0.001483413],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005507241,"threshold_uncertainty_score":0.0184235,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2510588976888302,"score_gpt":0.4569950793971614,"score_spread":0.2059361817083312,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}