{"id":"W2121789326","doi":"10.1124/jpet.110.173179","title":"Naturally Occurring Variants of Human Aldo-Keto Reductases with Reduced In Vitro Metabolism of Daunorubicin and Doxorubicin","year":2010,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Aldose Reductase and Taurine","field":"Biochemistry, Genetics and Molecular Biology","cited_by":100,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Daunorubicin; Metabolite; Nonsynonymous substitution; Metabolism; Chemistry; Doxorubicin; Single-nucleotide polymorphism; Nucleotide; In vitro; Biochemistry; Molecular biology; Biology; Gene; Genetics; Genotype; Chemotherapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003745012,0.0006494942,0.0004370363,0.0003161085,0.000297246,0.0004001549,0.0004175113,0.0005850928,0.00234715],"category_scores_gemma":[0.0007771271,0.0002161435,0.000531684,0.0003249909,0.0005786656,0.0001722769,0.0002884835,0.0008508989,0.0005952956],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004576932,"about_ca_system_score_gemma":0.0002739305,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001347502,"about_ca_topic_score_gemma":0.0009654445,"domain_scores_codex":[0.9995202,0.0001593361,0.00009445377,0.00008789194,0.00007263103,0.00006539627],"domain_scores_gemma":[0.9994266,0.0001784961,0.0001403946,0.0000706513,0.00005942813,0.0001244771],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002071094,0.0003141588,0.003442434,0.00006203901,0.0002113919,0.003935579,0.000178044,0.0006399025,0.9839624,0.001421507,0.0003378471,0.003423568],"study_design_scores_gemma":[0.0005868131,0.003057847,0.02303511,0.00002857506,0.0004684103,0.02877177,0.0003502255,0.007322741,0.9224937,0.001034081,0.01273936,0.0001114522],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952632,0.0004291075,0.002934608,0.0001559126,0.0001357095,0.00004019455,0.0004545325,0.0000654235,0.0005213299],"genre_scores_gemma":[0.9977347,0.0001096473,0.0008126727,0.0000400562,0.00002648126,0.00001464582,0.0004367415,0.0000431094,0.0007818752],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00234715,"threshold_uncertainty_score":0.007851958,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01133862869504186,"score_gpt":0.3178072629296804,"score_spread":0.3064686342346385,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}