{"id":"W2121872275","doi":"10.1124/jpet.103.055327","title":"Muscarinic Agonist-Mediated Heterologous Desensitization in Isolated Ileum Requires Activation of Both Muscarinic M2 and M3 Receptors","year":2004,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"National Institute of Neurological Disorders and Stroke","keywords":"Muscarinic acetylcholine receptor; Oxotremorine; Muscarinic agonist; Agonist; Endocrinology; Internal medicine; Muscarinic acetylcholine receptor M4; Acetylcholine; Muscarinic acetylcholine receptor M1; Muscarinic acetylcholine receptor M3; Chemistry; Homologous desensitization; Muscarinic acetylcholine receptor M2; Receptor; Desensitization (medicine); Muscarinic acetylcholine receptor M5; Biology; Pharmacology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007467783,0.000408362,0.0008291581,0.0002729709,0.0003770011,0.0006030943,0.0006779433,0.0005702048,0.00260325],"category_scores_gemma":[0.0006416944,0.0003800252,0.001054037,0.0003111407,0.0006283156,0.0009853443,0.0006179803,0.002216973,0.0007576098],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009103579,"about_ca_system_score_gemma":0.0003943577,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001117418,"about_ca_topic_score_gemma":0.002372319,"domain_scores_codex":[0.9993821,0.0001348028,0.00005237563,0.00008334316,0.0001025647,0.0002446827],"domain_scores_gemma":[0.9995322,0.0001701306,0.00004793237,0.0001335244,0.00004066214,0.00007565008],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001038212,0.00007120072,0.0001396006,0.00003642164,0.00000781903,0.00008855386,0.00004700419,0.00004721418,0.9978557,0.0001691005,0.00002973447,0.0004693076],"study_design_scores_gemma":[0.0001444313,0.001236943,0.01026215,0.00001483522,0.00002939179,0.0004278118,0.0001627671,0.001837194,0.9845249,0.0001202292,0.001229728,0.000009675705],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958274,0.0007915042,0.001302161,0.0001164884,0.00004542277,0.00005650632,0.0002647165,0.00002971464,0.001566076],"genre_scores_gemma":[0.994418,0.0005340244,0.001624428,0.000125464,0.0000242115,0.00005836956,0.0006514015,0.00003715336,0.002526979],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00260325,"threshold_uncertainty_score":0.008708775,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01496676799672579,"score_gpt":0.2953723548149966,"score_spread":0.2804055868182708,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}