{"id":"W2121877441","doi":"10.1158/0008-5472.can-04-4585","title":"Transforming Growth Factor-β Suppresses Nonmetastatic Colon Cancer through Smad4 and Adaptor Protein ELF at an Early Stage of Tumorigenesis","year":2005,"lang":"en","type":"article","venue":"Cancer Research","topic":"TGF-β signaling in diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":88,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institutes of Health; U.S. Department of Veterans Affairs","keywords":"Carcinogenesis; Biology; Cancer research; Transforming growth factor beta; Signal transducing adaptor protein; Progenitor cell; Cancer; Epithelial–mesenchymal transition; Wnt signaling pathway; SMAD; Stem cell; Transforming growth factor; Signal transduction; Endocrinology; Cell biology; Metastasis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002136516,0.0001746849,0.0002104782,0.00006651455,0.0001861435,0.00003698137,0.0002906235,0.00009979945,0.0002878291],"category_scores_gemma":[0.00007096396,0.0001628825,0.00005418802,0.0001505833,0.0002995217,0.00002957061,0.0001156896,0.0001373246,0.000002659891],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001047171,"about_ca_system_score_gemma":0.0004147076,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002106073,"about_ca_topic_score_gemma":0.001968784,"domain_scores_codex":[0.9981979,0.0001703535,0.0002425841,0.0004680717,0.0004431266,0.0004779379],"domain_scores_gemma":[0.9991395,0.00003823223,0.00006768006,0.0003090925,0.0002727029,0.000172832],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004666255,0.00009391068,0.00827925,0.000364512,0.00007370456,0.000004122086,0.0005660132,0.00008094522,0.9884061,0.00002653553,0.0001505075,0.00148783],"study_design_scores_gemma":[0.0005266017,0.0003637231,0.004035508,0.00008239863,0.00001548707,7.764107e-7,0.0001252396,0.00001666415,0.9838486,0.00001222559,0.01078719,0.0001855601],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925243,0.005781464,0.00009193668,0.0001034945,0.00003100957,0.0006575799,0.000740067,0.00001298203,0.00005720048],"genre_scores_gemma":[0.9961188,0.0008068011,0.0004129309,0.00002603631,0.000198698,0.0005000835,0.00004559666,0.00004710357,0.001843989],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01063669,"threshold_uncertainty_score":0.6642156,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0628780832858573,"score_gpt":0.3808923348475495,"score_spread":0.3180142515616922,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}