{"id":"W2121894182","doi":"10.1016/s0168-8278(09)60941-7","title":"939 PRECLINICAL PHARMACOKINETIC AND ADME CHARACTERIZATION OF VCH-222, A NOVEL NON-NUCLEOSIDE HCV NS5B POLYMERASE INHIBITOR","year":2009,"lang":"en","type":"article","venue":"Journal of Hepatology","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"BioPhage Pharma (Canada)","funders":"","keywords":"ADME; Pharmacokinetics; Pharmacology; Polymerase; Nucleoside; Virology; Chemistry; Medicine; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000550476,0.0004528387,0.0006652853,0.0002936602,0.0002287018,0.0006599777,0.0003414283,0.0003186493,0.00178015],"category_scores_gemma":[0.0006257831,0.0004315587,0.0004028818,0.0002461244,0.0003023917,0.0003813117,0.000109601,0.001250274,0.0004906242],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005754873,"about_ca_system_score_gemma":0.001078485,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003040382,"about_ca_topic_score_gemma":0.004921684,"domain_scores_codex":[0.9997658,0.00009408432,0.00001028872,0.00002656072,0.00005294919,0.00005036946],"domain_scores_gemma":[0.9998177,0.00004509639,0.000043011,0.0000194288,0.00002479451,0.00004998284],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.03726212,0.009442756,0.003659563,0.0002976314,0.0004072662,0.0003808,0.0002364068,0.008025523,0.8520831,0.0007093271,0.003854603,0.08364097],"study_design_scores_gemma":[0.008281028,0.1336577,0.02632873,0.00004291382,0.0009906173,0.001933991,0.000239032,0.03542637,0.7758783,0.0003980122,0.01669279,0.0001305675],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922796,0.001525427,0.002492763,0.0002018051,0.00006924294,0.0002028339,0.0007660199,0.0001377942,0.002324638],"genre_scores_gemma":[0.9945449,0.001048048,0.001383831,0.0001137471,0.0000351876,0.00006752466,0.0007431883,0.00005088326,0.002012694],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003040382,"threshold_uncertainty_score":0.006045341,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01650155133904074,"score_gpt":0.3074844762368338,"score_spread":0.290982924897793,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}