{"id":"W2121912512","doi":"10.1101/gad.254870.114","title":"A phosphorylation switch on RbBP5 regulates histone H3 Lys4 methylation","year":2015,"lang":"en","type":"article","venue":"Genes & Development","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Biology; Methyltransferase; Methylation; Histone methyltransferase; Histone H3; Protein subunit; Phosphorylation; Transferase; Histone; Biochemistry; Cell biology; Enzyme; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004914824,0.000196358,0.000143503,0.00008087639,0.0001094695,0.00002913977,0.0001244917,0.0001662058,0.00001834198],"category_scores_gemma":[0.00007119947,0.0001920927,0.00004926752,0.0001277429,0.00002673395,0.000005441107,0.00007420285,0.00005552934,0.00008124077],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000115256,"about_ca_system_score_gemma":0.0002382763,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001724838,"about_ca_topic_score_gemma":0.00003313763,"domain_scores_codex":[0.9986647,0.00006113883,0.0003235664,0.0004035523,0.0003117036,0.0002353836],"domain_scores_gemma":[0.9992033,0.00001101722,0.0001333864,0.0003050561,0.0002071746,0.0001400765],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001632599,0.0001013119,0.004054952,0.00001241848,0.00007132113,0.000002033793,0.0005962742,0.002652279,0.8125459,0.0001559514,0.001124474,0.1785198],"study_design_scores_gemma":[0.0004206761,0.000140386,0.01169837,0.000008916809,0.00001064644,0.000001081017,0.00004672368,0.0001128828,0.7978817,0.0004396238,0.1890087,0.0002302902],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9839112,0.005698112,0.007339714,0.0001598794,0.0004123195,0.0002404919,0.000002420973,0.00002887361,0.002206957],"genre_scores_gemma":[0.9851181,0.0003205313,0.01190864,0.000121086,0.0002071568,0.00004819383,0.0004044414,0.00003223289,0.001839654],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1878842,"threshold_uncertainty_score":0.7833313,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02637665844455659,"score_gpt":0.2836060950034979,"score_spread":0.2572294365589413,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}