{"id":"W2121927305","doi":"10.1128/aac.00529-09","title":"High-Throughput Screening Identifies Three Inhibitor Classes of the Telomere Resolvase from the Lyme Disease Spirochete","year":2009,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Vector-borne infectious diseases","field":"Immunology and Microbiology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Lyme disease; Telomere; Biology; Virology; Borrelia burgdorferi; Computational biology; Genetics; DNA; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008989732,0.0002765071,0.0003091073,0.00003503393,0.0004648675,0.00006958492,0.0003912074,0.0001443077,0.0004055259],"category_scores_gemma":[0.00004524916,0.000167755,0.0002209335,0.0001606104,0.0004505564,0.0001339172,0.000106399,0.0002098929,0.00002685378],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001968306,"about_ca_system_score_gemma":0.00005414865,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007660102,"about_ca_topic_score_gemma":0.000162568,"domain_scores_codex":[0.9987573,0.0001196747,0.0003378713,0.0003919817,0.00007211915,0.0003210743],"domain_scores_gemma":[0.9990353,0.0001066801,0.0002219718,0.0005321987,0.00006372228,0.00004012928],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001107745,0.0007976922,0.2181382,0.0000382502,0.0009245091,0.00001350186,0.0009101121,0.00002312653,0.594521,0.0004457751,0.1636059,0.01947421],"study_design_scores_gemma":[0.001982334,0.00008083826,0.8337043,0.0001527999,0.0001638692,0.000008165453,0.00007177807,0.000002858413,0.1487215,0.0007593989,0.0140999,0.000252286],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910418,0.001202749,0.00007368476,0.006410991,0.0005524276,0.0003516822,0.0002619057,0.00006179615,0.00004300651],"genre_scores_gemma":[0.9899216,0.0005153328,0.00003997538,0.008989009,0.0001902985,0.00000538218,0.00006861715,0.00002517263,0.0002446221],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6155661,"threshold_uncertainty_score":0.6840852,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01204897015591577,"score_gpt":0.2320380752279166,"score_spread":0.2199891050720009,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}