{"id":"W2121927305","doi":"10.1128/aac.00529-09","title":"High-Throughput Screening Identifies Three Inhibitor Classes of the Telomere Resolvase from the Lyme Disease Spirochete","year":2009,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Vector-borne infectious diseases","field":"Immunology and Microbiology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Lyme disease; Telomere; Biology; Virology; Borrelia burgdorferi; Computational biology; Genetics; DNA; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002177866,0.0006093714,0.0006856298,0.0004600438,0.0002246782,0.000504597,0.0003650843,0.0003585489,0.001101089],"category_scores_gemma":[0.0002807921,0.0001770211,0.0003093819,0.0003780109,0.0001955626,0.0001864628,0.0001695711,0.0004083017,0.00040608],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003486573,"about_ca_system_score_gemma":0.0002578947,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008167778,"about_ca_topic_score_gemma":0.002222851,"domain_scores_codex":[0.999803,0.00002975224,0.0000123391,0.00003214353,0.00008748248,0.0000352362],"domain_scores_gemma":[0.9998479,0.00006375476,0.00002301782,0.00001164174,0.00002745069,0.00002630405],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006658174,0.0007708506,0.001836096,0.0001838879,0.00006643196,0.0001047268,0.00002998283,0.001534395,0.9694986,0.0001102117,0.0004786635,0.02472033],"study_design_scores_gemma":[0.0001494605,0.003724536,0.006780765,0.000016492,0.0001555499,0.0004806398,0.00002345197,0.003534228,0.9815668,0.00003936616,0.003509068,0.00001968241],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9776585,0.008235018,0.008287224,0.0002639383,0.00004155705,0.0002942033,0.001780672,0.0003397653,0.003099064],"genre_scores_gemma":[0.9756179,0.00633681,0.009537678,0.0001422575,0.0000255627,0.000140119,0.004078234,0.00003510988,0.004086289],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001101089,"threshold_uncertainty_score":0.003683448,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01204897015591577,"score_gpt":0.2320380752279166,"score_spread":0.2199891050720009,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}