{"id":"W2121939895","doi":"10.1038/labinvest.2009.13","title":"Mitochondrial control of platelet apoptosis: effect of cyclosporin A, an inhibitor of the mitochondrial permeability transition pore","year":2009,"lang":"en","type":"article","venue":"Laboratory Investigation","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":104,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"Heart and Stroke Foundation of Canada","keywords":"MPTP; Apoptosis; Platelet; Mitochondrial permeability transition pore; Phosphatidylserine; Platelet activation; Biology; Cell biology; Immunology; Programmed cell death; Biochemistry; Endocrinology; Membrane; Phospholipid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002096086,0.000136399,0.0002389932,0.00003461091,0.00004354017,0.000004976323,0.0001148253,0.0002355859,0.000004996833],"category_scores_gemma":[0.0000947179,0.0001031155,0.0001126279,0.0001709555,0.0001600938,0.00001631391,0.000008247107,0.00007049937,1.667811e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001299175,"about_ca_system_score_gemma":0.000103264,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000127575,"about_ca_topic_score_gemma":0.000008063773,"domain_scores_codex":[0.9987617,0.0002886623,0.0004011683,0.0002273818,0.0002187272,0.0001024286],"domain_scores_gemma":[0.9990221,0.00001431241,0.0003241721,0.0003517262,0.000232469,0.00005519023],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004757264,0.00005927321,0.0005254237,0.00006426129,0.00001898598,9.548717e-8,0.0001889408,0.0006176643,0.9969532,0.0001783099,0.00003828351,0.0008798568],"study_design_scores_gemma":[0.001656405,0.001269038,0.006234742,0.00004511622,0.00005882765,7.026809e-7,0.00003171427,0.0002400215,0.9897988,0.0004815244,0.00008877569,0.0000943512],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977819,0.00009620541,0.0009014669,0.00009990084,0.0004410906,0.0005482707,0.0001132313,0.0000072921,0.00001068592],"genre_scores_gemma":[0.9988542,0.000008956091,0.0004818957,0.00005869892,0.0003651198,0.00001147483,0.0002052727,0.000009490658,0.000004889695],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007154398,"threshold_uncertainty_score":0.420493,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003747400039549189,"score_gpt":0.2088086687151133,"score_spread":0.2050612686755642,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}