{"id":"W2121949393","doi":"10.1210/me.2004-0032","title":"Crystal Structures of the Multispecific 17β-Hydroxysteroid Dehydrogenase Type 5: Critical Androgen Regulation in Human Peripheral Tissues","year":2004,"lang":"en","type":"article","venue":"Molecular Endocrinology","topic":"Aldose Reductase and Taurine","field":"Biochemistry, Genetics and Molecular Biology","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier de l'Université Laval","funders":"","keywords":"Biology; Hydroxysteroid dehydrogenase; Binding site; Testosterone (patch); Cofactor; Androgen receptor; Androgen; Dehydrogenase; Dihydrotestosterone; Androstenedione; Enzyme; Dehydroepiandrosterone; Biochemistry; Internal medicine; Endocrinology; Prostate cancer; Hormone; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003146152,0.000654299,0.0007582732,0.0001906415,0.0005619089,0.0008968589,0.0009590179,0.0007243159,0.002549964],"category_scores_gemma":[0.0006000895,0.0003812583,0.0002771063,0.0005187297,0.0002021983,0.0004013622,0.0003501135,0.001220773,0.0005398268],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001165704,"about_ca_system_score_gemma":0.0009660094,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005746232,"about_ca_topic_score_gemma":0.005528691,"domain_scores_codex":[0.9997923,0.00003174169,0.00001195265,0.00004375973,0.00007986271,0.00004044529],"domain_scores_gemma":[0.9998306,0.0000282309,0.00002924584,0.000007712026,0.00005190229,0.00005241912],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006145422,0.001631006,0.01519612,0.003890042,0.0006036736,0.004244556,0.002322694,0.02536948,0.7057705,0.02247775,0.09940293,0.1129459],"study_design_scores_gemma":[0.003491537,0.001826696,0.07157496,0.0004828486,0.001215515,0.009044808,0.002031185,0.09337968,0.3502412,0.008926447,0.4573349,0.000450167],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8978142,0.05921523,0.01178439,0.003279393,0.0005936775,0.0001923235,0.01016064,0.0008847131,0.01607553],"genre_scores_gemma":[0.924167,0.01771528,0.01935547,0.0006576806,0.00009303765,0.000165871,0.02663325,0.0001593499,0.01105303],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005746232,"threshold_uncertainty_score":0.01142561,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009791318735933963,"score_gpt":0.2735080374641883,"score_spread":0.2637167187282544,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}