{"id":"W2121981334","doi":"10.1186/1756-6606-2-5","title":"Cathepsin D expression level affects alpha-synuclein processing, aggregation, and toxicity in vivo","year":2009,"lang":"en","type":"article","venue":"Molecular Brain","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":281,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"National Institute of Neurological Disorders and Stroke; National Institutes of Health; Academy of Finland; Canada Research Chairs; European Commission","keywords":"Cathepsin D; Alpha-synuclein; Biology; Cell biology; Molecular biology; Gene expression; Biochemistry; Gene; Enzyme; Parkinson's disease; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001688336,0.0003235389,0.000208354,0.0002507006,0.0001354993,0.0003639629,0.0001532839,0.0003690879,0.001165437],"category_scores_gemma":[0.0001832802,0.0001182191,0.0002386744,0.0001863457,0.0003237734,0.0001616631,0.00014427,0.000433213,0.0002548547],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000484963,"about_ca_system_score_gemma":0.0002227111,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006105565,"about_ca_topic_score_gemma":0.0006218333,"domain_scores_codex":[0.9998323,0.00002491686,0.00002670719,0.00004781397,0.00002779469,0.00004044212],"domain_scores_gemma":[0.99977,0.00004744671,0.00007247119,0.00002416897,0.00002490122,0.00006100697],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004284129,0.00004335722,0.0003991127,0.00002233382,0.000006374154,0.0000421809,0.000006333054,0.00002386753,0.9986377,0.00002212583,0.00002154356,0.0003464358],"study_design_scores_gemma":[0.00002112774,0.0003516903,0.003607966,0.00000329714,0.00001827223,0.0001913191,0.00001213461,0.0003018041,0.9949778,0.00001762656,0.0004939578,0.000003061338],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965757,0.001071556,0.001015751,0.00006743359,0.00001468494,0.00002087504,0.0005259846,0.00003825487,0.0006697621],"genre_scores_gemma":[0.9947516,0.0006628379,0.001451543,0.0000434685,0.000008313397,0.00005059129,0.0009679497,0.00002016205,0.002043533],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001165437,"threshold_uncertainty_score":0.003898799,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01440826121371857,"score_gpt":0.2688224786398973,"score_spread":0.2544142174261788,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}