{"id":"W2122031040","doi":"10.1016/s0378-5173(00)00430-0","title":"Pharmacokinetics of metoprolol enantiomers following single and multiple administration of racemate in rat","year":2000,"lang":"en","type":"article","venue":"International Journal of Pharmaceutics","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Enantiomer; Pharmacokinetics; Oral administration; Metoprolol; Pharmacology; Chemistry; Stereospecificity; Absorption (acoustics); High-performance liquid chromatography; Dosing; Chromatography; Medicine; Stereochemistry; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000342739,0.0007324928,0.001208539,0.0006561176,0.0003218622,0.0007204799,0.0004317659,0.0008166505,0.002307022],"category_scores_gemma":[0.000912962,0.0006871655,0.0006080818,0.0004187436,0.0006908433,0.001280529,0.0001579401,0.00163641,0.00104832],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000641281,"about_ca_system_score_gemma":0.001021914,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002246039,"about_ca_topic_score_gemma":0.002149335,"domain_scores_codex":[0.9996676,0.00006323196,0.00001889199,0.00009353413,0.00006138928,0.00009529146],"domain_scores_gemma":[0.9993147,0.0001275673,0.0001837961,0.0001143776,0.00008136054,0.0001782195],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.1335028,0.002178052,0.003511528,0.000148617,0.0002754921,0.0004068447,0.0002697553,0.001687259,0.8137611,0.0008668191,0.001105356,0.04228635],"study_design_scores_gemma":[0.001427503,0.02524747,0.01491824,0.00001969221,0.000497609,0.0005597191,0.0002672758,0.006859036,0.9459686,0.0005401082,0.003576906,0.0001178191],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937976,0.001174446,0.00206148,0.0001816255,0.0001252285,0.00005851629,0.001114364,0.0002408443,0.001245969],"genre_scores_gemma":[0.9878067,0.001637914,0.002054931,0.0001223426,0.0001161093,0.0001206142,0.0009823573,0.0001292603,0.00702982],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002307022,"threshold_uncertainty_score":0.007717788,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02059680125686514,"score_gpt":0.3260979070066742,"score_spread":0.3055011057498091,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}