{"id":"W2122044626","doi":"10.1016/j.intimp.2007.04.002","title":"Effects of intravenous and subcutaneous administration on the pharmacokinetics, biodistribution, cellular uptake and immunostimulatory activity of CpG ODN encapsulated in liposomal nanoparticles","year":2007,"lang":"en","type":"article","venue":"International Immunopharmacology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":68,"is_retracted":false,"has_abstract":false,"ca_institutions":"Arbutus Biopharma (Canada); University of British Columbia","funders":"","keywords":"CpG Oligodeoxynucleotide; Biodistribution; Immune system; Antibody-dependent cell-mediated cytotoxicity; Spleen; Population; Pharmacology; Chemistry; Molecular biology; Mononuclear phagocyte system; Immunology; Biology; Antibody; Medicine; Biochemistry; Monoclonal antibody; DNA methylation; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003052654,0.0004535751,0.0003966255,0.0001770017,0.0001049848,0.0002392957,0.0002525715,0.0003874512,0.001527282],"category_scores_gemma":[0.0005550266,0.0002306848,0.0003452443,0.0002070481,0.000522296,0.0005179282,0.0001117511,0.0009722897,0.0002978034],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002548914,"about_ca_system_score_gemma":0.000495771,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001037797,"about_ca_topic_score_gemma":0.0008365661,"domain_scores_codex":[0.9998399,0.00003421405,0.00001133578,0.00003427999,0.00001968077,0.00006064346],"domain_scores_gemma":[0.9996076,0.0001869804,0.00006591104,0.00004429855,0.00003323036,0.00006192135],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.02780651,0.001221494,0.0004662975,0.0001646384,0.00004474334,0.0001758515,0.0001097722,0.0009185061,0.9546186,0.0002445362,0.0002865258,0.01394253],"study_design_scores_gemma":[0.0003341737,0.01199362,0.002768092,0.000009239228,0.00009159048,0.0001492624,0.00004486387,0.002764315,0.9805604,0.0001111761,0.001146731,0.00002641761],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970795,0.0009605727,0.0009495266,0.0000691708,0.0000835062,0.00002499943,0.0001892694,0.00004400845,0.000599408],"genre_scores_gemma":[0.9955322,0.0007113098,0.0006963942,0.00006069307,0.00004094619,0.00003977704,0.0002477547,0.00003270644,0.002638126],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001527282,"threshold_uncertainty_score":0.005109251,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007169558758728892,"score_gpt":0.2469786052876548,"score_spread":0.2398090465289259,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}