{"id":"W2122044626","doi":"10.1016/j.intimp.2007.04.002","title":"Effects of intravenous and subcutaneous administration on the pharmacokinetics, biodistribution, cellular uptake and immunostimulatory activity of CpG ODN encapsulated in liposomal nanoparticles","year":2007,"lang":"en","type":"article","venue":"International Immunopharmacology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":68,"is_retracted":false,"has_abstract":false,"ca_institutions":"Arbutus Biopharma (Canada); University of British Columbia","funders":"","keywords":"CpG Oligodeoxynucleotide; Biodistribution; Immune system; Antibody-dependent cell-mediated cytotoxicity; Spleen; Population; Pharmacology; Chemistry; Molecular biology; Mononuclear phagocyte system; Immunology; Biology; Antibody; Medicine; Biochemistry; Monoclonal antibody; DNA methylation; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003961629,0.0001643117,0.0002313531,0.0001903418,0.00008251167,0.000009507146,0.0001526681,0.000168092,0.0003422428],"category_scores_gemma":[0.0001402417,0.0001419103,0.00004975304,0.0001156361,0.0003768546,0.00008957787,0.00006644028,0.0003381918,0.0000165418],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006938975,"about_ca_system_score_gemma":0.00004153655,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001018549,"about_ca_topic_score_gemma":0.000006354071,"domain_scores_codex":[0.9988021,0.0002011582,0.0005019227,0.0002151237,0.00006560345,0.0002140784],"domain_scores_gemma":[0.9986656,0.0007628431,0.0002908098,0.000104054,0.0001595267,0.00001718786],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003676117,0.0005113361,0.000463711,0.00002724519,0.0002432423,0.00002915795,0.0002626245,0.00001633728,0.9875588,0.0008789333,0.0001204407,0.006212017],"study_design_scores_gemma":[0.002041777,0.0007504892,0.04934171,0.00003529679,0.00005730859,0.0001213524,0.00008030188,0.0001171434,0.9455808,0.00005060652,0.00171851,0.0001047444],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949997,0.001610405,0.0001017975,0.0003034116,0.002471662,0.0003300692,0.00001546488,0.00001827329,0.0001492061],"genre_scores_gemma":[0.9992937,0.0003285528,0.000006779715,0.000112795,0.00002421096,0.00001452903,0.00004254763,0.00000969652,0.000167144],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.048878,"threshold_uncertainty_score":0.5786934,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007169558758728892,"score_gpt":0.2469786052876548,"score_spread":0.2398090465289259,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}