{"id":"W2122047581","doi":"10.1093/hmg/dds199","title":"Evidence for an oligogenic basis of amyotrophic lateral sclerosis","year":2012,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":351,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"","keywords":"TARDBP; Biology; Genetics; Amyotrophic lateral sclerosis; C9orf72; Mutation; Penetrance; Gene; SOD1; Allele; Pathology; Disease; Medicine; Trinucleotide repeat expansion; Phenotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004887622,0.0003306722,0.0002601954,0.001137833,0.0003856649,0.0003281307,0.0005375323,0.0004796757,0.004541237],"category_scores_gemma":[0.003011487,0.0002143305,0.0002142133,0.0006221987,0.0008309346,0.0002453681,0.0007846492,0.0002999667,0.0005860823],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001937275,"about_ca_system_score_gemma":0.000233123,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007187973,"about_ca_topic_score_gemma":0.0007855181,"domain_scores_codex":[0.9992725,0.0002157747,0.00009227975,0.0001819813,0.0001522058,0.00008521233],"domain_scores_gemma":[0.9960179,0.001381784,0.00132489,0.0004048393,0.000389338,0.0004813692],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002114951,0.0001412215,0.9189197,0.0001338057,0.000272396,0.01364468,0.0002992412,0.0001705306,0.04988518,0.001002394,0.0003838454,0.01303199],"study_design_scores_gemma":[0.00007053382,0.0004617173,0.9396904,0.00006174557,0.0001890525,0.05102513,0.0002050527,0.0008573827,0.004433163,0.0008428282,0.0021418,0.00002116626],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975088,0.0005895753,0.0006214567,0.00005549356,0.000008678691,0.000007210288,0.0001583259,0.00001537445,0.001035051],"genre_scores_gemma":[0.9989067,0.0002433514,0.0003359401,0.0000461362,0.00001965954,0.0000089622,0.0002454873,0.000008128013,0.0001855727],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004541237,"threshold_uncertainty_score":0.01519197,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2490781509360899,"score_gpt":0.3979464163657339,"score_spread":0.148868265429644,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}