{"id":"W2122091775","doi":"10.1038/nature13909","title":"Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS","year":2014,"lang":"en","type":"article","venue":"Nature","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2804,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; National Heart, Lung, and Blood Institute; Medical Research Council; Canadian Institutes of Health Research; British Heart Foundation","keywords":"Reactive oxygen species; Mitochondrial ROS; Reperfusion injury; Mitochondrion; Ischemia; Citric acid cycle; Cell biology; Succinate dehydrogenase; Biology; In vivo; Biochemistry; Chemistry; Pharmacology; Metabolism; Medicine; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004489344,0.0004176867,0.000419107,0.0003388202,0.0003403609,0.0009082885,0.0003867266,0.0004977896,0.001706816],"category_scores_gemma":[0.0003917944,0.0003252751,0.0003048091,0.000243987,0.0007016483,0.001118715,0.0003843613,0.0007225189,0.0003632054],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007416087,"about_ca_system_score_gemma":0.0004221566,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005383244,"about_ca_topic_score_gemma":0.001201572,"domain_scores_codex":[0.9997811,0.00002636176,0.00002839458,0.00004860893,0.0000416723,0.0000738923],"domain_scores_gemma":[0.9996364,0.00002912899,0.0001197484,0.00007214103,0.00003942063,0.0001030508],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003527869,0.00008716962,0.0005317336,0.00003934453,0.0000123212,0.00006237449,0.00004288526,0.00009089761,0.9924392,0.000760245,0.0001239638,0.002282088],"study_design_scores_gemma":[0.0001658167,0.0007853022,0.0117846,0.00001524731,0.00003952513,0.0002024404,0.00007912097,0.001641701,0.9825051,0.001154019,0.001610892,0.00001618798],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9859425,0.003303829,0.007452376,0.0007794066,0.0002452563,0.00004745985,0.0003046544,0.0001842858,0.001740194],"genre_scores_gemma":[0.9965044,0.0006761852,0.001013932,0.00006296553,0.00003778586,0.00001692445,0.0001521422,0.00002908396,0.001506603],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001706816,"threshold_uncertainty_score":0.005709827,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0132552309320221,"score_gpt":0.3027477406537396,"score_spread":0.2894925097217175,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}