{"id":"W2122101813","doi":"10.1021/jm801575w","title":"Allosteric Modulation of the Dopamine D <sub>2</sub> Receptor by Pro-Leu-Gly-NH <sub>2</sub> Peptidomimetics Constrained in Either a Polyproline II Helix or a Type II β-Turn Conformation","year":2009,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Institute of Neurological Disorders and Stroke","keywords":"Polyproline helix; Chemistry; Allosteric regulation; Peptidomimetic; Stereochemistry; Dopamine; Helix (gastropod); Dopamine receptor; Receptor; Intrinsic activity; Biochemistry; Peptide; Neuroscience; Agonist","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001149173,0.0002019678,0.0001890621,0.00006259244,0.0000439323,0.0001537499,0.0001222703,0.0001341834,0.0006820562],"category_scores_gemma":[0.0001212924,0.00008429212,0.0001159857,0.00005280162,0.0001214578,0.0001038545,0.00009261796,0.0002270988,0.0001953695],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001303882,"about_ca_system_score_gemma":0.00008970679,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001248694,"about_ca_topic_score_gemma":0.0002806519,"domain_scores_codex":[0.9999424,0.00001525273,0.000005154843,0.000008914861,0.00001328669,0.00001510429],"domain_scores_gemma":[0.9999574,0.000008099935,0.00001812063,0.00000252975,0.000002598289,0.00001114936],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003445794,0.00004153245,0.0001551804,0.00003932401,0.000006671397,0.00006283497,0.00001305743,0.0005218817,0.9949028,0.0002105117,0.00003481038,0.003666782],"study_design_scores_gemma":[0.0001400958,0.002767299,0.001623865,0.000006455737,0.00002239876,0.0004062948,0.00001859058,0.00227128,0.9907969,0.00007225323,0.001863158,0.00001143453],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963527,0.0007446564,0.001287893,0.0000325193,0.00002034385,0.00002433906,0.00007278376,0.00002769051,0.001437182],"genre_scores_gemma":[0.9966453,0.0004304854,0.002197264,0.00005303622,0.000006312407,0.00001295124,0.000079584,0.000004983729,0.0005700582],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006820562,"threshold_uncertainty_score":0.002281725,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006560467945537148,"score_gpt":0.2245704947866448,"score_spread":0.2180100268411076,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}