{"id":"W2122101813","doi":"10.1021/jm801575w","title":"Allosteric Modulation of the Dopamine D <sub>2</sub> Receptor by Pro-Leu-Gly-NH <sub>2</sub> Peptidomimetics Constrained in Either a Polyproline II Helix or a Type II β-Turn Conformation","year":2009,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Institute of Neurological Disorders and Stroke","keywords":"Polyproline helix; Chemistry; Allosteric regulation; Peptidomimetic; Stereochemistry; Dopamine; Helix (gastropod); Dopamine receptor; Receptor; Intrinsic activity; Biochemistry; Peptide; Neuroscience; Agonist","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000471213,0.000235625,0.000448312,0.00005018187,0.00007619095,0.000010327,0.0002741289,0.0002571152,0.00005421979],"category_scores_gemma":[0.0005483929,0.0001549672,0.0002163863,0.0002980682,0.0001440627,0.00001675998,0.00007481374,0.0003106354,8.909525e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006331909,"about_ca_system_score_gemma":0.0001965317,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002301534,"about_ca_topic_score_gemma":0.000002555226,"domain_scores_codex":[0.9981287,0.00004826479,0.0009135279,0.0001999325,0.0004641014,0.0002454505],"domain_scores_gemma":[0.998383,0.0000313063,0.0008715357,0.0002433515,0.0003302904,0.0001404452],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008215985,0.0002734772,0.000158068,0.00006704198,0.00009069858,0.000003855481,0.00008060664,0.0000400647,0.985306,4.66363e-7,0.001232652,0.01192549],"study_design_scores_gemma":[0.001658539,0.0006332834,0.0003224787,0.0002772185,0.0001242598,0.0001356979,0.0001407578,0.0004399767,0.9951744,0.00001630078,0.0009047862,0.0001723038],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974837,0.0007697849,0.0001414195,0.001227194,0.00006349185,0.0001262254,0.00002257659,0.000004102209,0.000161557],"genre_scores_gemma":[0.9983664,0.0006209456,0.0001435992,0.000251646,0.0004210273,0.000002690403,0.0000686472,0.00001566589,0.000109452],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01175319,"threshold_uncertainty_score":0.631938,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006560467945537148,"score_gpt":0.2245704947866448,"score_spread":0.2180100268411076,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}