{"id":"W2122129374","doi":"10.1093/hmg/ddn024","title":"Loss of RB1 induces non-proliferative retinoma: increasing genomic instability correlates with progression to retinoblastoma","year":2008,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Ocular Oncology and Treatments","field":"Medicine","cited_by":353,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network; Hospital for Sick Children; Canada Research Chairs; Princess Margaret Cancer Centre; Ontario Institute for Cancer Research","funders":"","keywords":"Retinoblastoma; Biology; Genome instability; Suppressor; Cancer research; Chromosome instability; Tumor suppressor gene; Senescence; Gene; Genetics; Cancer; Tumor progression; Retinoblastoma protein; Carcinogenesis; Cell cycle; DNA damage; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001581571,0.000234193,0.0004094376,0.0001133564,0.000196443,0.000007633372,0.0001054936,0.000177219,0.0000252969],"category_scores_gemma":[0.0000560328,0.0001897014,0.00007749809,0.0001940583,0.000368563,0.00002406088,0.0001001929,0.0002158185,0.00001868032],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009823626,"about_ca_system_score_gemma":0.0002019624,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002003771,"about_ca_topic_score_gemma":0.00001053193,"domain_scores_codex":[0.9985691,0.0001507669,0.0003327815,0.0003971977,0.0002836416,0.0002664967],"domain_scores_gemma":[0.9989574,0.00003025189,0.0001616355,0.0004459929,0.0002209055,0.0001838169],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008014065,0.0005306104,0.7216317,0.00005531092,0.0001734546,0.0009963311,0.001515119,0.00004878628,0.2737527,0.00003579666,0.00001104761,0.0004477443],"study_design_scores_gemma":[0.002089886,0.003552239,0.7513199,0.000179205,0.0001841947,0.0005059591,0.00007846732,0.00004284853,0.2417532,0.00008364778,0.00003261014,0.0001779052],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973091,0.0003882662,0.0002471644,0.00007420481,0.00003390743,0.0009546198,0.000005236463,0.00003139437,0.0009560764],"genre_scores_gemma":[0.9887784,0.00001646086,0.01091425,0.0001270756,0.0000330339,0.00003601197,0.00003236491,0.0000387539,0.00002368681],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03199952,"threshold_uncertainty_score":0.7735798,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01654260183069186,"score_gpt":0.2920422380864056,"score_spread":0.2754996362557138,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}