{"id":"W2122134392","doi":"10.1093/hmg/ddp588","title":"Pkd1 transgenic mice: adult model of polycystic kidney disease with extrarenal and renal phenotypes","year":2010,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Genetic and Kidney Cyst Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research; School of Medicine, Indiana University; PKD Australia","keywords":"PKD1; Biology; Autosomal dominant polycystic kidney disease; Genetically modified mouse; Kidney; Transgene; Polycystic kidney disease; Endocrinology; Internal medicine; Phenotype; Fibrosis; Cyst; Pathology; Gene; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00005741972,0.0003008627,0.0002124819,0.00006485124,0.0001071851,0.00002989459,0.0002661537,0.0001490407,0.00003245992],"category_scores_gemma":[0.00005599977,0.0002790641,0.0001188332,0.00007092071,0.0003688149,0.000003313025,0.00007950162,0.000145943,0.00000211186],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003450443,"about_ca_system_score_gemma":0.0003548397,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006986624,"about_ca_topic_score_gemma":0.00002795447,"domain_scores_codex":[0.9985539,0.00004136369,0.0002836938,0.0005150527,0.0002708383,0.0003351914],"domain_scores_gemma":[0.9984599,0.000004746016,0.0001031207,0.0005661618,0.0001742471,0.0006918719],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000304628,0.0001238733,0.001121969,0.00008287841,0.00009504022,0.000007474706,0.00006050495,0.0008059841,0.9966273,0.0004000558,0.0002167101,0.0001535757],"study_design_scores_gemma":[0.002805056,0.0006448735,0.01732943,0.00007969764,0.0006373491,0.00002709611,0.00004128564,0.003618206,0.9705253,0.0022275,0.001175742,0.0008885267],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9851932,0.001140559,0.01266797,0.00008047015,0.000053794,0.0002562617,0.0002101468,0.00001529004,0.0003823073],"genre_scores_gemma":[0.9919851,0.0001015988,0.006895557,0.0004079741,0.000119106,0.00002611068,0.000243587,0.00006221482,0.0001587769],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02610207,"threshold_uncertainty_score":0.9999661,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006163040318280658,"score_gpt":0.2236770604701646,"score_spread":0.217514020151884,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}