{"id":"W2122147772","doi":"10.1152/ajpregu.90829.2008","title":"Increased prolyl 4-hydroxylase expression and differential regulation of hypoxia-inducible factors in the aged rat brain","year":2009,"lang":"en","type":"article","venue":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women's Health Research Institute","funders":"National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences","keywords":"Downregulation and upregulation; Hypoxia (environmental); Biology; Internal medicine; Endocrinology; Cerebral cortex; Gene expression; Transcription factor; Messenger RNA; Cortex (anatomy); Hypoxia-inducible factors; In vivo; Regulation of gene expression; Cell biology; Gene; Neuroscience; Chemistry; Biochemistry; Medicine; Oxygen; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001088443,0.0003169916,0.0002866485,0.0004969081,0.0001097217,0.0001772805,0.0001239627,0.000123023,0.0008547332],"category_scores_gemma":[0.0001268942,0.0001900515,0.0001993604,0.0001285066,0.0002523486,0.0002344381,0.0001839641,0.0003837929,0.0001956762],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002548997,"about_ca_system_score_gemma":0.0001914424,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000882971,"about_ca_topic_score_gemma":0.001024568,"domain_scores_codex":[0.9999312,0.000005215051,0.000006414243,0.00002176734,0.00001515631,0.00002022506],"domain_scores_gemma":[0.9998468,0.000006387193,0.00007161894,0.00001243218,0.00002293455,0.00003980432],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004379553,0.00002751344,0.001360068,0.00003763146,0.00001111607,0.0001633771,0.00004537091,0.00002034011,0.9960507,0.0000558298,0.00003058328,0.001759636],"study_design_scores_gemma":[0.00005468045,0.002071133,0.203105,0.00001824443,0.0001159731,0.00207296,0.0002583889,0.0004250296,0.7896457,0.0004141961,0.00179596,0.00002276073],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997589,0.00136239,0.0005495835,0.00002918322,0.00001610191,0.000003167082,0.0001776271,0.00001795866,0.0002550753],"genre_scores_gemma":[0.994867,0.001840862,0.000726829,0.00004616366,0.00001572598,0.000020498,0.000446248,0.00001186512,0.002024853],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000882971,"threshold_uncertainty_score":0.002859354,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01480632971972841,"score_gpt":0.2697749295084827,"score_spread":0.2549685997887543,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}