{"id":"W2122203297","doi":"10.1093/hmg/ddq156","title":"Genetic variants at 2q24 are associated with susceptibility to type 2 diabetes","year":2010,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":198,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Center for Research Resources; National Institute of Dental and Craniofacial Research; National Institute of Environmental Health Sciences; National Human Genome Research Institute; National Institute on Drug Abuse; National Heart, Lung, and Blood Institute; National Cancer Institute; National Institute on Alcohol Abuse and Alcoholism; American Heart Association; Canadian Institutes of Health Research; U.S. Public Health Service; National Institutes of Health; Fondation Leducq; Broad Institute; National Institute of Diabetes and Digestive and Kidney Diseases; Johns Hopkins University; Amgen; School of Medicine, Boston University; Massachusetts General Hospital; Donald W. Reynolds Foundation","keywords":"Biology; Genome-wide association study; Type 2 diabetes; Locus (genetics); Genetics; Insulin resistance; Allele; SNP; Genetic association; Single-nucleotide polymorphism; Case-control study; Gene; Diabetes mellitus; Internal medicine; Endocrinology; Genotype; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000306317,0.0003323018,0.0003380125,0.00007262569,0.0002619302,0.00003694501,0.000400468,0.0004104933,0.000151354],"category_scores_gemma":[0.0005396231,0.0003222291,0.0001100315,0.0002328108,0.0001610192,0.000001832601,0.0003199207,0.000227214,0.00007263952],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004551206,"about_ca_system_score_gemma":0.00008598503,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001264304,"about_ca_topic_score_gemma":0.001715251,"domain_scores_codex":[0.9977524,0.0001969596,0.0003810458,0.0007664806,0.0002428058,0.000660333],"domain_scores_gemma":[0.9980873,0.00002804086,0.0002211684,0.00100162,0.0003677693,0.000294083],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00001336767,0.00007931335,0.3607538,0.00000479271,0.00009872918,0.000007175948,0.00002342885,0.0005223537,0.6367177,0.00001553657,0.001609447,0.0001543631],"study_design_scores_gemma":[0.0004903993,0.0007185802,0.9658501,0.00001096222,0.00007400485,0.000006640216,0.00001758932,0.00009915428,0.02870819,0.000256373,0.003321897,0.0004461369],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976132,0.0002636601,0.0006219086,0.0001549187,0.0002546179,0.0004026698,0.00003954771,0.00003314014,0.0006163236],"genre_scores_gemma":[0.9925012,0.0000207984,0.00531094,0.0009976738,0.0001777903,0.00003842414,0.0002108374,0.0000771952,0.0006651591],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6080095,"threshold_uncertainty_score":0.999923,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01160239225487413,"score_gpt":0.2526516502146008,"score_spread":0.2410492579597267,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}