{"id":"W2122205071","doi":"10.1016/s0092-8674(03)00930-9","title":"EMSY Links the BRCA2 Pathway to Sporadic Breast and Ovarian Cancer","year":2003,"lang":"en","type":"article","venue":"Cell","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":423,"is_retracted":false,"has_abstract":false,"ca_institutions":"Vancouver General Hospital; University of British Columbia; BC Cancer Agency","funders":"Medical Research Council; Wellcome Trust","keywords":"Biology; BRCA2 Protein; Ovarian cancer; Breast cancer; Exon; Cancer research; Gene silencing; Gene; Chromatin; Cancer; Genetics; Mutation; Germline mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001612171,0.0004151448,0.0002681979,0.0007431829,0.000300232,0.0004389769,0.0002846373,0.000526453,0.004251931],"category_scores_gemma":[0.0003430605,0.0002323864,0.0001795468,0.0003828963,0.0003765643,0.0002821804,0.0004685011,0.0004955581,0.0005979243],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003922855,"about_ca_system_score_gemma":0.0002965887,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001057652,"about_ca_topic_score_gemma":0.001040568,"domain_scores_codex":[0.9999118,0.00002047056,0.000005379443,0.00001696152,0.00002087841,0.00002453611],"domain_scores_gemma":[0.9998275,0.00004976881,0.00005006883,0.00002570243,0.00001533887,0.00003150967],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001034041,0.0001119891,0.008421071,0.0001442465,0.00005637807,0.004454209,0.00007381337,0.0009685312,0.9631296,0.005475038,0.00160243,0.01452856],"study_design_scores_gemma":[0.0001292432,0.0003855593,0.05807172,0.00002824738,0.0000841197,0.01186985,0.0001595671,0.002728208,0.8975958,0.006525086,0.02240157,0.00002096516],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9792581,0.005547821,0.005370659,0.001626067,0.0001172593,0.00002153053,0.001067575,0.0003691834,0.006621743],"genre_scores_gemma":[0.991266,0.001942495,0.0009045461,0.0001772562,0.00003577399,0.00001291833,0.0004420376,0.00003363246,0.005185398],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004251931,"threshold_uncertainty_score":0.01422411,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008171401343159239,"score_gpt":0.2369563140982113,"score_spread":0.2287849127550521,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}