{"id":"W2122227569","doi":"10.1158/1078-0432.ccr-1115-03","title":"Predictive Models for Breast Cancer Susceptibility from Multiple Single Nucleotide Polymorphisms","year":2004,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":200,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Alberta Cancer Foundation","funders":"","keywords":"Single-nucleotide polymorphism; Breast cancer; SNP; Biology; Genetics; Cancer; Genotype; Computational biology; Oncology; Bioinformatics; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001364816,0.0002032429,0.0003205695,0.00004794501,0.0001924803,0.00004611087,0.0005319423,0.0003755422,0.0001706682],"category_scores_gemma":[0.0005118503,0.0001905242,0.0002907746,0.000161965,0.0005100135,0.00001586297,0.0003839866,0.0004257407,0.00001702522],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002687725,"about_ca_system_score_gemma":0.0007848902,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0041153,"about_ca_topic_score_gemma":0.004549916,"domain_scores_codex":[0.9969351,0.0002638859,0.0005099244,0.001106175,0.0004791562,0.0007057799],"domain_scores_gemma":[0.9978215,0.0002805184,0.00009792717,0.0007899759,0.0006590242,0.0003511022],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005336061,0.001259611,0.01628029,0.00004512613,0.000328173,0.000007839057,0.0001351094,0.004130168,0.9416477,0.0001568506,0.003992248,0.0266808],"study_design_scores_gemma":[0.01141709,0.003882141,0.03241469,0.0002743235,0.0001094918,0.000005326997,0.0003566654,0.008154046,0.8940018,0.03925719,0.009154902,0.0009723711],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9837235,0.001204211,0.008502461,0.001547925,0.0006856071,0.001065439,0.003010785,0.00004660599,0.0002134886],"genre_scores_gemma":[0.9943778,0.0005460038,0.001572191,0.0003520101,0.00196817,0.0005862536,0.0001199618,0.00006721781,0.0004103848],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04764595,"threshold_uncertainty_score":0.776935,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1299888912551065,"score_gpt":0.4278457033816551,"score_spread":0.2978568121265486,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}