{"id":"W2122234004","doi":"10.1021/bi901330g","title":"Identification and Characterization of Binding Sites on S100A7, a Participant in Cancer and Inflammation Pathways","year":2009,"lang":"en","type":"article","venue":"Biochemistry","topic":"S100 Proteins and Annexins","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; University of Victoria","funders":"Canadian Institutes of Health Research","keywords":"Isothermal titration calorimetry; Chemistry; Fluorescence; Molecule; Binding site; Stereochemistry; Titration; Crystallography; Biophysics; Biochemistry; Biology; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007801194,0.00006785479,0.00006959572,0.00002592183,0.00002288273,0.00001431732,0.00003069011,0.00007945039,0.000003074211],"category_scores_gemma":[0.00003244272,0.00006732456,0.00001213971,0.00004939823,0.00002510546,0.000004662756,0.00001431374,0.00002913622,3.374353e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000656386,"about_ca_system_score_gemma":0.0000175696,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005233177,"about_ca_topic_score_gemma":0.00000351968,"domain_scores_codex":[0.9995415,0.000008171698,0.0001496427,0.0001702347,0.00004895158,0.0000815379],"domain_scores_gemma":[0.9997632,0.000002585457,0.00008564426,0.00009732119,0.00002430881,0.00002696214],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002876844,0.00002437985,0.003845936,0.00003131834,0.000003916973,3.739941e-7,0.00005978451,0.000001492506,0.9903638,0.00003543071,0.000005493811,0.005599343],"study_design_scores_gemma":[0.0001890677,0.00006238198,0.05342918,0.00004742392,0.000004917295,0.000001112855,0.00003287711,0.0001213311,0.9459714,0.00002255746,0.00004720614,0.00007049046],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995059,0.0001776105,0.0000225101,0.0001404681,0.00001154059,0.00008366058,0.00002108185,0.000004276341,0.00003294363],"genre_scores_gemma":[0.9994141,0.000259358,0.00001870301,0.00002888092,0.00006037208,0.0000150084,0.0001268935,0.000004235558,0.00007241284],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04958324,"threshold_uncertainty_score":0.2745416,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02362935731076503,"score_gpt":0.2644943376220551,"score_spread":0.2408649803112901,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}