{"id":"W2122234004","doi":"10.1021/bi901330g","title":"Identification and Characterization of Binding Sites on S100A7, a Participant in Cancer and Inflammation Pathways","year":2009,"lang":"en","type":"article","venue":"Biochemistry","topic":"S100 Proteins and Annexins","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; University of Victoria","funders":"Canadian Institutes of Health Research","keywords":"Isothermal titration calorimetry; Chemistry; Fluorescence; Molecule; Binding site; Stereochemistry; Titration; Crystallography; Biophysics; Biochemistry; Biology; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008023324,0.0001814209,0.0002238759,0.0001950161,0.0001231457,0.0001251371,0.0002067335,0.0003114328,0.001325519],"category_scores_gemma":[0.0002237442,0.0001253228,0.0002380417,0.0001476265,0.00009477923,0.0001069365,0.0001157786,0.0002515595,0.0004943734],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001539577,"about_ca_system_score_gemma":0.00009824301,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008865496,"about_ca_topic_score_gemma":0.0009492085,"domain_scores_codex":[0.9999243,0.00001141422,0.000003632036,0.00001442829,0.00002899817,0.0000173229],"domain_scores_gemma":[0.9999028,0.00002672564,0.00001359972,0.0000102269,0.00002264661,0.00002397031],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004233011,0.00001380622,0.0003359406,0.00001465805,0.000003777698,0.0000271278,0.000008532544,0.00006741303,0.9984469,0.00003292751,0.000017558,0.0009889629],"study_design_scores_gemma":[0.00001046774,0.0002261306,0.0236576,0.000007605489,0.00001889169,0.0004578627,0.00005396174,0.004519549,0.9679197,0.0001090086,0.003011698,0.000007393389],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950777,0.0008192083,0.002914219,0.00003672417,0.000003996468,0.00001710286,0.0001852349,0.00001716976,0.0009284347],"genre_scores_gemma":[0.9912264,0.0005938623,0.004894956,0.00006004527,0.000003663019,0.00003352173,0.0009286203,0.00001256995,0.002246398],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001325519,"threshold_uncertainty_score":0.004434288,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02362935731076503,"score_gpt":0.2644943376220551,"score_spread":0.2408649803112901,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}