{"id":"W2122249218","doi":"10.1053/j.gastro.2011.04.057","title":"Single Nucleotide Polymorphisms That Increase Expression of the Guanosine Triphosphatase RAC1 Are Associated With Ulcerative Colitis","year":2011,"lang":"en","type":"article","venue":"Gastroenterology","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":71,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; Hospital for Sick Children; University of Toronto; Mount Sinai Hospital; SickKids Foundation","funders":"Action Medical Research; Ontario Ministry of Research and Innovation; Canadian Institutes of Health Research; Medical Research Council; Canadian Child Health Clinician Scientist Program; National Institute of Diabetes and Digestive and Kidney Diseases; Crohn's and Colitis Foundation of Canada; Crohn's and Colitis Foundation; Canadian Association of Gastroenterology; Scottish Government; Hospital for Sick Children; Wellcome Trust","keywords":"Guanosine; Ulcerative colitis; Single-nucleotide polymorphism; Triphosphatase; Nucleotide; RAC1; Biology; Chemistry; Genetics; Gene; Medicine; Internal medicine; Genotype; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000146627,0.0002388557,0.0002905457,0.00003726386,0.00009815321,0.000009090029,0.0003840637,0.0001282482,0.00009360858],"category_scores_gemma":[0.0002226383,0.0001693751,0.00009155696,0.00010204,0.0004069878,0.00001179699,0.0002997074,0.0001232954,0.000002658891],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002790907,"about_ca_system_score_gemma":0.00004610651,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001635123,"about_ca_topic_score_gemma":0.0006083951,"domain_scores_codex":[0.9984712,0.000318398,0.0002587037,0.0003835381,0.0001640705,0.0004041185],"domain_scores_gemma":[0.9986857,0.00001792455,0.0004751142,0.0005684592,0.0001467052,0.0001060719],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0129004,0.001282306,0.5752555,0.00002388409,0.0002676139,0.00007748907,0.0001898752,0.000009195554,0.3975039,0.0001232998,0.01201872,0.0003478979],"study_design_scores_gemma":[0.001601053,0.001304459,0.2693503,0.00007279478,0.0000427386,0.00003160665,0.00004323603,0.000001801145,0.7271808,0.0000296874,0.0002532787,0.00008815499],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974327,0.0006264087,0.0003983934,0.0001537011,0.0001499327,0.0003954351,0.0007300886,0.00001796673,0.00009536451],"genre_scores_gemma":[0.9980356,0.00002136005,0.0005519738,0.0008305424,0.0000517691,0.00005691442,0.0003274354,0.00003280454,0.00009158893],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.329677,"threshold_uncertainty_score":0.6906917,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01545216351682436,"score_gpt":0.2053138131444285,"score_spread":0.1898616496276042,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}