{"id":"W2122263972","doi":"10.1128/iai.71.1.196-204.2003","title":"4-1BB (CD137) Differentially Regulates Murine In Vivo Protein- and Polysaccharide-Specific Immunoglobulin Isotype Responses to<i>Streptococcus pneumoniae</i>","year":2002,"lang":"en","type":"article","venue":"Infection and Immunity","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; Uniformed Services University of the Health Sciences; National Institutes of Health; U.S. Department of Defense","keywords":"CD137; Biology; Isotype; Antigen; Germinal center; CD28; Antibody; Immunoglobulin class switching; T cell; Streptococcus pneumoniae; Molecular biology; CD8; Immunology; Microbiology; Monoclonal antibody; Immune system; B cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002091122,0.000579324,0.0004224863,0.0003257975,0.0001873985,0.0005265609,0.0003525856,0.0005148997,0.00117912],"category_scores_gemma":[0.0002003504,0.0002575314,0.0003199147,0.0001335626,0.0004039133,0.0002621208,0.0002310544,0.001129866,0.0006508348],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008755937,"about_ca_system_score_gemma":0.0003871272,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001007786,"about_ca_topic_score_gemma":0.001475028,"domain_scores_codex":[0.9995067,0.0001001755,0.00004525703,0.00006850986,0.00009737715,0.0001819509],"domain_scores_gemma":[0.9996302,0.00004580736,0.0001419179,0.00002374148,0.00003212982,0.0001261303],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002532919,0.00008498081,0.0001563512,0.00001973711,0.000003438678,0.00003071113,0.00001123395,0.00005998708,0.9987457,0.00006944205,0.00003118012,0.0005340536],"study_design_scores_gemma":[0.00006534176,0.0008694335,0.004665107,0.000009313912,0.00003341916,0.0002264427,0.00003581649,0.0009699986,0.9917036,0.00005654324,0.001357484,0.000007404272],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971559,0.0005150829,0.0007564108,0.00008302581,0.00002167593,0.00002937075,0.0002021164,0.00008923541,0.001147186],"genre_scores_gemma":[0.9957073,0.0003710107,0.0008200862,0.00008543302,0.00001563338,0.00004025515,0.0004453356,0.00003709638,0.00247781],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00117912,"threshold_uncertainty_score":0.006352901,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01622501556466314,"score_gpt":0.2211935408054379,"score_spread":0.2049685252407748,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}