{"id":"W2122305079","doi":"10.1074/jbc.m008495200","title":"Aromatic Hydrocarbon Receptor (AhR)·AhR Nuclear Translocator- and p53-mediated Induction of the Murine Multidrug Resistance mdr1 Gene by 3-Methylcholanthrene and Benzo(a)pyrene in Hepatoma Cells","year":2001,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute","funders":"","keywords":"Aryl hydrocarbon receptor nuclear translocator; Aryl hydrocarbon receptor; Molecular biology; Transcription factor; Chemistry; Chromatin immunoprecipitation; Benzo(a)pyrene; Transcription (linguistics); Promoter; Gene expression; Pyrene; Translocator protein; Carcinogen; Gene; Biology; Biochemistry; Inflammation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001339108,0.0002973537,0.0001960736,0.000303254,0.0001443985,0.000157893,0.0001251116,0.0001772293,0.001647303],"category_scores_gemma":[0.00006628498,0.0001472644,0.0003281407,0.0001879495,0.0001839827,0.0001305569,0.0001807404,0.0005283821,0.0005239699],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002397381,"about_ca_system_score_gemma":0.0001790063,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006679023,"about_ca_topic_score_gemma":0.00110815,"domain_scores_codex":[0.9998019,0.00003669628,0.00001785322,0.00003264557,0.00006684448,0.00004394806],"domain_scores_gemma":[0.9999057,0.00001184153,0.00002807723,0.0000126874,0.00001382341,0.0000278574],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006336482,0.00002177827,0.00007863747,0.00001120523,0.000002025987,0.00002553752,0.000007566442,0.00002275434,0.9992226,0.00003392121,0.00001621263,0.0004943636],"study_design_scores_gemma":[0.00002420778,0.0003352074,0.003920301,0.000003546423,0.000007143621,0.0001222308,0.000009467489,0.0003552295,0.9936357,0.00001933529,0.001564752,0.000002962537],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942877,0.00133151,0.002191052,0.00009080414,0.00002948215,0.00006172329,0.000719717,0.00009975556,0.001188255],"genre_scores_gemma":[0.9873111,0.001082714,0.00353389,0.00004839122,0.00001330151,0.000110635,0.001936153,0.00002382489,0.005939957],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001647303,"threshold_uncertainty_score":0.005510747,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009683043821226981,"score_gpt":0.2118921754774837,"score_spread":0.2022091316562567,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}