{"id":"W2122313788","doi":"10.1074/jbc.m409420200","title":"CD4 Down-regulation by HIV-1 and Simian Immunodeficiency Virus (SIV) Nef Proteins Involves Both Internalization and Intracellular Retention Mechanisms","year":2004,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"National Institute of Allergy and Infectious Diseases; Uniformed Services University of the Health Sciences; National Institutes of Health","keywords":"Endocytosis; Internalization; Simian immunodeficiency virus; Intracellular; Biology; Cell biology; Signal transducing adaptor protein; Clathrin; Gene knockdown; Virology; Virus; Cell; Cell culture; Signal transduction; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001609057,0.000373621,0.0002379962,0.0003469945,0.0003438985,0.0006141245,0.0003278649,0.000363636,0.003989191],"category_scores_gemma":[0.0002274351,0.0001675193,0.0005332454,0.0001617849,0.0002633972,0.0003184382,0.0006590981,0.0008082241,0.0008576686],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008022942,"about_ca_system_score_gemma":0.0003448967,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001242965,"about_ca_topic_score_gemma":0.001868054,"domain_scores_codex":[0.99972,0.00004083075,0.000016298,0.0000480715,0.00008506671,0.00008959483],"domain_scores_gemma":[0.9998785,0.00002149899,0.00002401146,0.00001223843,0.00003822698,0.00002551958],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003273773,0.0001102067,0.002109324,0.0001437245,0.00004362024,0.0002749818,0.00009030785,0.0001589599,0.9616926,0.002427141,0.0008113495,0.03181043],"study_design_scores_gemma":[0.0001095283,0.000545738,0.04334529,0.00008671155,0.00008021097,0.001827724,0.0002587655,0.002296204,0.8715045,0.0008896069,0.07903156,0.00002414893],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9374437,0.0288375,0.005383126,0.0004979971,0.0003073208,0.00009120827,0.0002862486,0.0001421275,0.02701077],"genre_scores_gemma":[0.9601323,0.007350483,0.005621355,0.0003381516,0.00008504344,0.00008375188,0.0005699083,0.00003723896,0.02578171],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003989191,"threshold_uncertainty_score":0.01334518,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01341239922743479,"score_gpt":0.2274530624402822,"score_spread":0.2140406632128475,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}