{"id":"W2122379385","doi":"10.1084/jem.20020735","title":"Failure to Censor Forbidden Clones of CD4 T Cells in Autoimmune Diabetes","year":2002,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":136,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; National Institutes of Health","keywords":"Biology; Clonal deletion; Immunology; Central tolerance; Major histocompatibility complex; Congenic; Autoimmunity; Antigen; NOD mice; Nod; Autoimmune disease; T cell; Autoantibody; Immune tolerance; T-cell receptor; Antibody; Genetics; Gene; Immune system","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002701967,0.0001003103,0.0002323279,0.00006122697,0.00002367046,0.000002815522,0.0002259169,0.00005176874,0.0001433435],"category_scores_gemma":[0.00005769869,0.00006227814,0.00006036837,0.0001090249,0.00008817588,0.000004341329,0.00005281097,0.0000851098,0.000003656799],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001417632,"about_ca_system_score_gemma":0.000007450864,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001647807,"about_ca_topic_score_gemma":0.000005158419,"domain_scores_codex":[0.9991887,0.0000584582,0.0003438496,0.00006876153,0.000167638,0.0001726214],"domain_scores_gemma":[0.9995354,0.00002601051,0.0001974407,0.0001349798,0.0000482203,0.00005793934],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004106638,0.0001316839,0.001032302,0.000005066124,0.00004742176,0.000001219763,0.0008349853,0.00003231821,0.9891475,0.000005676025,0.008185119,0.000535661],"study_design_scores_gemma":[0.001355635,0.001650965,0.001358016,0.0001219877,0.00002419719,0.000003999249,0.003721466,0.00002119071,0.9830726,0.00001462209,0.008572087,0.00008326718],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9867761,0.0107009,0.00000569284,0.001720374,0.0001674981,0.000120413,0.00000342454,0.00000140301,0.0005042651],"genre_scores_gemma":[0.9987832,0.0002975694,0.0001216964,0.000437761,0.0001339065,0.000002749196,0.000002453119,0.00001135782,0.0002092665],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01200721,"threshold_uncertainty_score":0.2539629,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008740515023062544,"score_gpt":0.2423388179882872,"score_spread":0.2335983029652246,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}