{"id":"W2122379385","doi":"10.1084/jem.20020735","title":"Failure to Censor Forbidden Clones of CD4 T Cells in Autoimmune Diabetes","year":2002,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":136,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; National Institutes of Health","keywords":"Biology; Clonal deletion; Immunology; Central tolerance; Major histocompatibility complex; Congenic; Autoimmunity; Antigen; NOD mice; Nod; Autoimmune disease; T cell; Autoantibody; Immune tolerance; T-cell receptor; Antibody; Genetics; Gene; Immune system","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001827567,0.0001593922,0.0001845154,0.0001558285,0.0001464032,0.0002819765,0.0001783243,0.0002951979,0.0006711704],"category_scores_gemma":[0.0003386582,0.0001122884,0.0001166239,0.00008072656,0.0001920148,0.0001555077,0.0002593508,0.0004568294,0.0002427068],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001197443,"about_ca_system_score_gemma":0.00009440228,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002160299,"about_ca_topic_score_gemma":0.0003573719,"domain_scores_codex":[0.99981,0.00002935147,0.00001620111,0.00004918423,0.00004908298,0.00004608685],"domain_scores_gemma":[0.9996082,0.00009333005,0.00009780328,0.00008278195,0.00003451125,0.00008328915],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001423292,0.00002863292,0.005278549,0.00002783293,0.00001068256,0.0002429355,0.00004156169,0.0001372943,0.9890752,0.000189115,0.00003974086,0.004786078],"study_design_scores_gemma":[0.00005313434,0.0008982237,0.04134331,0.00002100129,0.00005908414,0.007796836,0.00008179055,0.001799491,0.9437166,0.000317416,0.003901892,0.00001135853],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969591,0.0007425162,0.00174278,0.00001426377,0.000005229378,0.000004885784,0.00003495342,0.00004965789,0.0004466198],"genre_scores_gemma":[0.9981819,0.000235105,0.0005783521,0.00002229978,0.000003761961,0.000007804284,0.0001159843,0.00001503308,0.0008396996],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006711704,"threshold_uncertainty_score":0.002245307,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008740515023062544,"score_gpt":0.2423388179882872,"score_spread":0.2335983029652246,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}