{"id":"W2122417188","doi":"10.4049/jimmunol.174.1.340","title":"The Functional and Structural Properties of MD-2 Required for Lipopolysaccharide Binding Are Absent in MD-1","year":2005,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Mutant; Chemistry; Lipopolysaccharide; Alanine; Binding site; Mutation; Biochemistry; Transmembrane protein; Transfection; Escherichia coli; Molecular biology; Gene; Biology; Amino acid; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009288376,0.00009617933,0.0002315987,0.0001270293,0.0002467829,0.00000900319,0.0002093104,0.0001157448,0.00002476125],"category_scores_gemma":[0.0002504373,0.00004883843,0.00007027037,0.00005096273,0.0003664873,0.000149855,0.00005648547,0.0002725269,0.000007592579],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004888134,"about_ca_system_score_gemma":0.00007191451,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002447052,"about_ca_topic_score_gemma":0.00003868445,"domain_scores_codex":[0.9988502,0.0002997586,0.0005548772,0.00005816443,0.00003473301,0.0002022573],"domain_scores_gemma":[0.998781,0.0003667789,0.0005703542,0.0001348522,0.0001416622,0.000005342898],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003498358,0.00001394728,0.0003053409,0.000007868437,0.0002109796,4.161135e-7,0.0008898207,0.00004495435,0.9855134,0.0005809484,0.0004095524,0.00852438],"study_design_scores_gemma":[0.001934627,0.0003696028,0.01181246,0.00009917804,0.00005658815,0.0006739884,0.002944113,0.00002503433,0.9748453,0.0003153561,0.006839361,0.00008440188],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9542235,0.04276453,0.00004806347,0.002249456,0.000549164,0.000147481,0.000001915813,0.000003876859,0.00001209001],"genre_scores_gemma":[0.9966318,0.002952795,0.0000230964,0.0000380108,0.00006110346,0.000004995776,0.000001786599,0.000006820467,0.0002796072],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04240835,"threshold_uncertainty_score":0.1991573,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02180830836058902,"score_gpt":0.2338378900854883,"score_spread":0.2120295817248993,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}