{"id":"W2122429955","doi":"10.1085/jgp.201010573","title":"Mode shift of the voltage sensors in Shaker K+ channels is caused by energetic coupling to the pore domain","year":2011,"lang":"en","type":"article","venue":"The Journal of General Physiology","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Canadian Institutes of Health Research","keywords":"Gating; Shaker; Conformational change; Chemistry; Depolarization; Biophysics; Membrane potential; Voltage clamp; Voltage; Linker; Chemical physics; Vibration; Stereochemistry; Biochemistry; Physics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001465483,0.0002542846,0.0002391801,0.0001149757,0.0001373772,0.0001834801,0.0003137525,0.0002891843,0.0008968589],"category_scores_gemma":[0.0003112487,0.0001539976,0.0002261362,0.00009010253,0.0004836204,0.0003537959,0.0003472218,0.0005895642,0.0002431137],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002567187,"about_ca_system_score_gemma":0.0001433171,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002042033,"about_ca_topic_score_gemma":0.0002378345,"domain_scores_codex":[0.999867,0.0000196959,0.00001532686,0.00003743651,0.00003802072,0.00002250231],"domain_scores_gemma":[0.9997658,0.00005070529,0.00009205767,0.00003012952,0.00001627186,0.00004505996],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006891618,0.0000119329,0.00024317,0.00001175309,0.000002944025,0.00003117379,0.00001676512,0.0000810319,0.998743,0.0000754694,0.000005823757,0.0007080382],"study_design_scores_gemma":[0.00001353439,0.0002491252,0.007232293,0.000004146,0.000007655098,0.0002208041,0.00002363952,0.001493211,0.9902982,0.0001392498,0.0003067345,0.0000112927],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981374,0.0001006897,0.001531776,0.00001946816,0.000006112471,0.000003220278,0.00002088091,0.00002687618,0.0001536601],"genre_scores_gemma":[0.9985008,0.0000604209,0.000945379,0.00001763647,0.000003146973,0.000008641108,0.00005011353,0.00001211293,0.0004018788],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008968589,"threshold_uncertainty_score":0.003000319,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01485416627191037,"score_gpt":0.2368518877997954,"score_spread":0.221997721527885,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}