{"id":"W2122453581","doi":"10.2337/db09-1562","title":"NOX2 Deficiency Protects Against Streptozotocin-Induced β-Cell Destruction and Development of Diabetes in Mice","year":2010,"lang":"en","type":"article","venue":"Diabetes","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute","funders":"Canadian Institutes of Health Research; National Institutes of Health","keywords":"Insulitis; Streptozotocin; Internal medicine; Endocrinology; Apocynin; NADPH oxidase; Insulin; Reactive oxygen species; Splenocyte; Islet; Proinflammatory cytokine; Diabetes mellitus; Type 1 diabetes; Cytokine; Chemistry; Biology; Medicine; Oxidative stress; Biochemistry; Inflammation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002667061,0.0008808005,0.0004921033,0.0005605932,0.0001785326,0.0003768706,0.000329548,0.0004012251,0.00169212],"category_scores_gemma":[0.0001468705,0.0002393461,0.0003922179,0.0002472392,0.0002730341,0.0003494101,0.0002639196,0.0007113442,0.0003384644],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002142811,"about_ca_system_score_gemma":0.0002792258,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002789565,"about_ca_topic_score_gemma":0.0003606153,"domain_scores_codex":[0.9997992,0.0000249477,0.00002394845,0.00005625462,0.00004680416,0.00004887785],"domain_scores_gemma":[0.9997001,0.00001249952,0.0001187872,0.00002736459,0.00002238553,0.0001188378],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009727393,0.0002357796,0.0006623085,0.00008321748,0.00002265185,0.0000694636,0.00001694853,0.00005940879,0.9959356,0.00008718057,0.00005947263,0.001795326],"study_design_scores_gemma":[0.0003174101,0.003360323,0.01883273,0.00006305929,0.0001299231,0.0006151877,0.00007822487,0.001359483,0.9713739,0.0001592336,0.003694391,0.00001609971],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927528,0.001842207,0.003232931,0.0001305864,0.00008179363,0.00006671881,0.0006214256,0.0002196211,0.001051985],"genre_scores_gemma":[0.9869698,0.002753734,0.004012068,0.0001697911,0.0000570772,0.0001834829,0.001445351,0.00008413305,0.004324393],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00169212,"threshold_uncertainty_score":0.005660713,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01080109012696766,"score_gpt":0.2107768264591384,"score_spread":0.1999757363321708,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}