{"id":"W2122453581","doi":"10.2337/db09-1562","title":"NOX2 Deficiency Protects Against Streptozotocin-Induced β-Cell Destruction and Development of Diabetes in Mice","year":2010,"lang":"en","type":"article","venue":"Diabetes","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute","funders":"Canadian Institutes of Health Research; National Institutes of Health","keywords":"Insulitis; Streptozotocin; Internal medicine; Endocrinology; Apocynin; NADPH oxidase; Insulin; Reactive oxygen species; Splenocyte; Islet; Proinflammatory cytokine; Diabetes mellitus; Type 1 diabetes; Cytokine; Chemistry; Biology; Medicine; Oxidative stress; Biochemistry; Inflammation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002533769,0.0001941039,0.0002794008,0.0001811167,0.0001212894,0.00001155072,0.0001483103,0.0002079831,0.00005318169],"category_scores_gemma":[0.00005994656,0.0001738834,0.00003054056,0.0001595131,0.0001177133,0.0001069013,0.0000847808,0.0003416913,0.00004724208],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001803923,"about_ca_system_score_gemma":0.00007715535,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008119357,"about_ca_topic_score_gemma":0.00003591104,"domain_scores_codex":[0.9988339,0.00008380094,0.0003278002,0.0003292996,0.0000402788,0.0003849172],"domain_scores_gemma":[0.9995282,0.000071979,0.0001428563,0.0001669212,0.00006323592,0.00002676901],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000005935937,0.0001138307,0.02849471,0.00006564309,0.00001526356,5.174908e-7,0.0003729525,3.899577e-7,0.956869,0.0001242339,0.000005403403,0.0139321],"study_design_scores_gemma":[0.0007712096,0.0001198239,0.02768829,0.00004326963,0.000006253902,4.427349e-7,0.0001795412,0.000003928275,0.9706705,0.0001409765,0.000184134,0.0001916497],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986509,0.0002605118,0.000007485952,0.00002037282,0.0003252134,0.000476826,0.000007958904,0.00003342779,0.0002172959],"genre_scores_gemma":[0.9983565,0.000004859343,0.001395237,0.00004704138,0.00001238897,0.00009546924,0.00003254379,0.00001640266,0.00003953949],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01380146,"threshold_uncertainty_score":0.7090761,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01080109012696766,"score_gpt":0.2107768264591384,"score_spread":0.1999757363321708,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}