{"id":"W2122456689","doi":"10.1186/1479-5876-9-137","title":"Generation of high-titer viral preparations by concentration using successive rounds of ultracentrifugation","year":2011,"lang":"en","type":"article","venue":"Journal of Translational Medicine","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Sunnybrook Health Science Centre","funders":"National Cancer Institute; Canadian Institutes of Health Research; National Institutes of Health; Health Sciences Centre Foundation","keywords":"Titer; Ultracentrifuge; Virology; Chromatography; Medicine; Chemistry; Virus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003689229,0.00008308197,0.0001787157,0.00007810799,0.00003681153,0.00000335782,0.00009973342,0.00008157564,0.0001369478],"category_scores_gemma":[0.00006721065,0.00006934442,0.00006325456,0.0001017475,0.0001317267,0.00003164517,0.000003575978,0.0000747681,2.22975e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001651956,"about_ca_system_score_gemma":0.0001792956,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003053744,"about_ca_topic_score_gemma":0.0000208919,"domain_scores_codex":[0.9987262,0.0001056278,0.0005904766,0.00009745016,0.0003903777,0.00008988146],"domain_scores_gemma":[0.9987091,0.00002656111,0.0004953161,0.00009563677,0.0006216913,0.00005168459],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001274375,0.00008570656,0.001830692,0.00001480375,0.00009997921,6.07894e-7,0.0005617367,0.001769347,0.9933013,0.0001426917,0.0002582193,0.0006605592],"study_design_scores_gemma":[0.001795601,0.00245523,0.001908541,0.00004970718,0.0000709131,0.00001382096,0.00005086362,0.002327951,0.9909486,0.0002241234,0.00008846657,0.00006624687],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9363415,0.0012002,0.06184208,0.000256657,0.0001342259,0.000125549,0.00002889311,0.000001015286,0.00006988939],"genre_scores_gemma":[0.997342,0.0001420637,0.001871914,0.00003817419,0.0003883363,0.000001453308,0.0001804536,0.000008544686,0.00002708189],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06100048,"threshold_uncertainty_score":0.2827784,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06447697537164003,"score_gpt":0.3436040428034999,"score_spread":0.2791270674318598,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}