{"id":"W2122461299","doi":"10.1517/13543784.17.5.811","title":"Roflumilast: an oral, once-daily selective PDE-4 inhibitor for the management of COPD and asthma","year":2008,"lang":"en","type":"review","venue":"Expert Opinion on Investigational Drugs","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Foothills Medical Centre","funders":"","keywords":"Roflumilast; Medicine; COPD; Asthma; Intensive care medicine; Lung function; Internal medicine; Lung","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005187616,0.0007082398,0.001460985,0.002515296,0.0002447326,0.0006026668,0.000895759,0.0010773,0.003967277],"category_scores_gemma":[0.0005447615,0.0001948434,0.0006230438,0.001883053,0.0002504722,0.0008729792,0.0003012938,0.0009359697,0.002066797],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005241663,"about_ca_system_score_gemma":0.0009879721,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009168521,"about_ca_topic_score_gemma":0.002044877,"domain_scores_codex":[0.9998176,0.00002964111,0.00003031335,0.00002702919,0.00007537925,0.00002025747],"domain_scores_gemma":[0.9997829,0.00007894418,0.000053416,0.000004281779,0.00005890364,0.0000217004],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001660772,0.00008038971,0.0001847188,0.02725581,0.0001493488,0.0005059993,0.00003958692,0.0001271298,0.003339436,0.000499555,0.01808527,0.9495667],"study_design_scores_gemma":[0.0002459709,0.0005717408,0.003268732,0.01120719,0.0007348624,0.009157599,0.0001134134,0.0001796336,0.002775765,0.0008896485,0.9708095,0.0000459576],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002103909,0.9983572,0.0000937342,0.0002341402,0.0001549025,0.00001064266,0.00001811964,0.000007641085,0.000913182],"genre_scores_gemma":[0.001195525,0.9973802,0.0002354441,0.0002316741,0.0001658377,0.00001418722,0.00004306295,0.000001157547,0.0007329478],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003967277,"threshold_uncertainty_score":0.01327187,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04072050588806207,"score_gpt":0.3306587140258579,"score_spread":0.2899382081377958,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}