{"id":"W2122466511","doi":"10.1074/jbc.m207800200","title":"17-Epiestriol, an Estrogen Metabolite, Is More Potent Than Estradiol in Inhibiting Vascular Cell Adhesion Molecule 1 (VCAM-1) mRNA Expression","year":2003,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; National Institutes of Health; Pfizer; American Heart Association","keywords":"VCAM-1; Cell adhesion molecule; Metabolite; Estrogen; Chemistry; Messenger RNA; Cell adhesion; Cell biology; Cell; Biology; Biochemistry; Endocrinology; Gene","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005526183,0.0003485418,0.0004627063,0.00005240775,0.0000875616,0.00003557131,0.0003449059,0.0007294369,0.00003745398],"category_scores_gemma":[0.0002234705,0.0002492084,0.0004237937,0.0001695401,0.0001151124,0.00001863297,0.0000860636,0.0006262824,0.000002667718],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004088231,"about_ca_system_score_gemma":0.0001103965,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003482869,"about_ca_topic_score_gemma":8.208894e-8,"domain_scores_codex":[0.9978934,0.0002178227,0.0006865199,0.0004542852,0.0002836602,0.0004643055],"domain_scores_gemma":[0.9987292,0.00002908813,0.0004433669,0.0003289286,0.0001234118,0.0003459661],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001317842,0.0003392308,0.006404763,0.00003087412,0.00004849413,0.0001350039,0.00004247275,0.0001110472,0.9923804,0.000003744673,0.0001370064,0.0002351521],"study_design_scores_gemma":[0.001251338,0.0005357151,0.001020909,0.00008263687,0.00004088775,0.0003213237,0.0002739292,0.00001945927,0.9948192,0.0000676119,0.001259799,0.0003071938],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9887989,0.01003699,0.0001313275,0.00004358501,0.00006293971,0.0001342782,0.00001079071,0.00001096761,0.0007702448],"genre_scores_gemma":[0.9960994,0.001510661,0.001844035,0.0001371074,0.0002333458,0.000006849871,0.00006167215,0.00002675549,0.00008016059],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008526334,"threshold_uncertainty_score":0.999996,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01101802268180575,"score_gpt":0.239090799611312,"score_spread":0.2280727769295063,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}