{"id":"W2122466511","doi":"10.1074/jbc.m207800200","title":"17-Epiestriol, an Estrogen Metabolite, Is More Potent Than Estradiol in Inhibiting Vascular Cell Adhesion Molecule 1 (VCAM-1) mRNA Expression","year":2003,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; National Institutes of Health; Pfizer; American Heart Association","keywords":"VCAM-1; Cell adhesion molecule; Metabolite; Estrogen; Chemistry; Messenger RNA; Cell adhesion; Cell biology; Cell; Biology; Biochemistry; Endocrinology; Gene","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001944861,0.0002578281,0.0002677255,0.000144316,0.00008778809,0.000264929,0.00009821744,0.0001908066,0.001567048],"category_scores_gemma":[0.0001429111,0.0001064474,0.0001560115,0.0001522345,0.0001308747,0.0001836273,0.00008175825,0.0002457445,0.0002912859],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001398663,"about_ca_system_score_gemma":0.0001576941,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002375983,"about_ca_topic_score_gemma":0.0004178936,"domain_scores_codex":[0.999893,0.00002073815,0.00001450197,0.0000249523,0.00002945645,0.00001731789],"domain_scores_gemma":[0.9998957,0.00003274305,0.00002532181,0.000009426653,0.00001299072,0.00002386448],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000131327,0.0000311442,0.0003524572,0.00005223109,0.000007387752,0.00004681607,0.00000937821,0.00003766641,0.9975066,0.0000342151,0.00001297819,0.001777978],"study_design_scores_gemma":[0.00001732508,0.0007952233,0.006833071,0.00000579256,0.00001791212,0.0003283639,0.00002139552,0.0001039951,0.9884619,0.00002165524,0.00339081,0.000002640116],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9878313,0.00837891,0.001581845,0.00009021365,0.00003637276,0.00001907046,0.0002384089,0.00002326068,0.001800696],"genre_scores_gemma":[0.9876523,0.005020298,0.002158658,0.00009402176,0.00003358824,0.00002861503,0.000625842,0.00001300318,0.004373734],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001567048,"threshold_uncertainty_score":0.005242229,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01101802268180575,"score_gpt":0.239090799611312,"score_spread":0.2280727769295063,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}