{"id":"W2122489686","doi":"10.1016/j.vaccine.2009.05.094","title":"A novel vaccine adjuvant comprised of a synthetic innate defence regulator peptide and CpG oligonucleotide links innate and adaptive immunity","year":2009,"lang":"en","type":"article","venue":"Vaccine","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":80,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta; University of Saskatchewan; University of British Columbia; Dalhousie University; Izaak Walton Killam Health Centre; Institute of Infection and Immunity","funders":"Canadian Institutes of Health Research; Canada Research Chairs; Cystic Fibrosis Foundation; Bill and Melinda Gates Foundation","keywords":"Adjuvant; CpG Oligodeoxynucleotide; Innate immune system; Immunology; Biology; Chemokine; Immune system; CpG site; Acquired immune system; Toxoid; TLR9; Immunization; DNA methylation; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004258302,0.0002521957,0.0005464738,0.0002351545,0.0001708168,0.00001337331,0.0001722747,0.0002888089,0.00007930773],"category_scores_gemma":[0.0001833794,0.0002172059,0.00005992621,0.0002200569,0.00004846123,0.0001756209,0.0001271689,0.0004619219,0.00002553278],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002435037,"about_ca_system_score_gemma":0.00004280823,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001352872,"about_ca_topic_score_gemma":0.00001881705,"domain_scores_codex":[0.9986324,0.0001846578,0.000535737,0.0002921331,0.00004311945,0.0003119997],"domain_scores_gemma":[0.9989343,0.0001884371,0.0002883423,0.0003881368,0.0001646346,0.00003619842],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0021729,0.0001448868,0.001003411,0.00003230471,0.0001322755,0.000004366366,0.0007389685,0.00001150656,0.9815836,0.001417627,0.0002253288,0.01253281],"study_design_scores_gemma":[0.006279668,0.001217181,0.5870441,0.0003314207,0.0001417072,0.0003075908,0.0003152317,0.0004240736,0.4006216,0.0007321763,0.002208789,0.0003764625],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993476,0.004442621,0.000461832,0.0009082306,0.0000905823,0.0003300246,0.00001637861,0.00005942141,0.0002149607],"genre_scores_gemma":[0.9984326,0.000543885,0.0003901879,0.000175646,0.00001480741,0.00001005601,0.00003091144,0.00001572663,0.0003861922],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5860407,"threshold_uncertainty_score":0.8857401,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009804206835505489,"score_gpt":0.2205468924573732,"score_spread":0.2107426856218678,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}