{"id":"W2122489686","doi":"10.1016/j.vaccine.2009.05.094","title":"A novel vaccine adjuvant comprised of a synthetic innate defence regulator peptide and CpG oligonucleotide links innate and adaptive immunity","year":2009,"lang":"en","type":"article","venue":"Vaccine","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":80,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta; University of Saskatchewan; University of British Columbia; Dalhousie University; Izaak Walton Killam Health Centre; Institute of Infection and Immunity","funders":"Canadian Institutes of Health Research; Canada Research Chairs; Cystic Fibrosis Foundation; Bill and Melinda Gates Foundation","keywords":"Adjuvant; CpG Oligodeoxynucleotide; Innate immune system; Immunology; Biology; Chemokine; Immune system; CpG site; Acquired immune system; Toxoid; TLR9; Immunization; DNA methylation; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002428239,0.0004214732,0.0003440008,0.0002024901,0.000117541,0.0002396693,0.0002326766,0.0004864916,0.0009844735],"category_scores_gemma":[0.0001938289,0.0001593659,0.0001795187,0.00009819281,0.0001939849,0.0003620949,0.0003371922,0.0006224283,0.0003479943],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000170931,"about_ca_system_score_gemma":0.0003859056,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001154026,"about_ca_topic_score_gemma":0.0002974563,"domain_scores_codex":[0.9999082,0.00001712503,0.000007357318,0.0000172111,0.00002665942,0.0000233721],"domain_scores_gemma":[0.9999238,0.00001651814,0.00001526726,0.000006355055,0.0000155327,0.00002254785],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002000125,0.0001615158,0.0001458567,0.00007238287,0.000006325233,0.00006392958,0.000008099067,0.0002669076,0.9892417,0.0004052568,0.0001249988,0.009303031],"study_design_scores_gemma":[0.0002078136,0.003438153,0.0009155815,0.00002453792,0.00006615627,0.0007596535,0.00001895335,0.004057088,0.9816404,0.0003661971,0.008492221,0.00001330421],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9569968,0.003772138,0.0348639,0.0005463671,0.0005204614,0.0001951584,0.0001619912,0.0002298322,0.00271343],"genre_scores_gemma":[0.9624249,0.00157085,0.03159478,0.000319968,0.000113612,0.0001052073,0.0002491381,0.0000214806,0.003600131],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009844735,"threshold_uncertainty_score":0.003293335,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009804206835505489,"score_gpt":0.2205468924573732,"score_spread":0.2107426856218678,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}