{"id":"W2122570253","doi":"10.1128/aac.44.7.1887-1893.2000","title":"Itraconazole Oral Solution for Primary Prophylaxis of Fungal Infections in Patients with Hematological Malignancy and Profound Neutropenia: a Randomized, Double-Blind, Double-Placebo, Multicenter Trial Comparing Itraconazole and Amphotericin B","year":2000,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":157,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotel Dieu Hospital","funders":"","keywords":"Itraconazole; Neutropenia; Amphotericin B; Medicine; Aspergillosis; Placebo; Internal medicine; Mycosis; Population; Gastroenterology; Chemotherapy; Surgery; Immunology; Dermatology; Pathology; Antifungal","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002875857,0.000245758,0.0008974501,0.00008008092,0.000131688,0.00004781092,0.00004578122,0.0001477025,0.00006294862],"category_scores_gemma":[0.000006598946,0.0001747093,0.00009520452,0.0001110191,0.0003324301,0.0001830893,0.00002287752,0.0001716217,8.894958e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003468809,"about_ca_system_score_gemma":0.00004754125,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001660989,"about_ca_topic_score_gemma":0.0001009183,"domain_scores_codex":[0.9985765,0.00005763805,0.0005055882,0.0004226163,0.0001427882,0.0002948559],"domain_scores_gemma":[0.9994745,0.00005952263,0.0001440971,0.0001366949,0.00009385569,0.00009136062],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6501952,0.001115363,0.3446254,0.0002798988,0.00009474636,0.000002917442,0.0002012268,0.000001251777,0.00117243,0.0000143712,0.00006187708,0.002235294],"study_design_scores_gemma":[0.7513249,0.001014938,0.2458043,0.000192465,0.0001091447,0.00001312858,0.00001777644,0.0001294735,0.001031751,0.000007506044,0.0001720967,0.0001824691],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945004,0.00007446479,0.0001222469,0.0002464618,0.00004723513,0.004840438,0.00001588505,0.00001864548,0.000134243],"genre_scores_gemma":[0.9982929,0.0003081645,0.0006162024,0.0003948634,0.00003654376,0.0000962858,0.00005596177,0.00002193918,0.0001771821],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1011297,"threshold_uncertainty_score":0.7124439,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0226234012405232,"score_gpt":0.2774331805484901,"score_spread":0.2548097793079669,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}