{"id":"W2122570253","doi":"10.1128/aac.44.7.1887-1893.2000","title":"Itraconazole Oral Solution for Primary Prophylaxis of Fungal Infections in Patients with Hematological Malignancy and Profound Neutropenia: a Randomized, Double-Blind, Double-Placebo, Multicenter Trial Comparing Itraconazole and Amphotericin B","year":2000,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":157,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotel Dieu Hospital","funders":"","keywords":"Itraconazole; Neutropenia; Amphotericin B; Medicine; Aspergillosis; Placebo; Internal medicine; Mycosis; Population; Gastroenterology; Chemotherapy; Surgery; Immunology; Dermatology; Pathology; Antifungal","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001670997,0.001306425,0.003224284,0.0004894625,0.0003311321,0.0008547071,0.0007829764,0.00195627,0.003708438],"category_scores_gemma":[0.001931887,0.0006152226,0.001488025,0.000395193,0.001089491,0.0007344297,0.0003883764,0.002187484,0.0005959978],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004273431,"about_ca_system_score_gemma":0.001015935,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000452442,"about_ca_topic_score_gemma":0.0007310504,"domain_scores_codex":[0.9992793,0.0004152124,0.00005660834,0.0001115617,0.00004865594,0.00008867944],"domain_scores_gemma":[0.9987915,0.0003600768,0.0002465546,0.00006995066,0.00006486101,0.0004670661],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9663711,0.00718241,0.0006565778,0.0006091095,0.000581295,0.00005667543,0.0000386942,0.0002085061,0.004961826,0.00009089987,0.0004719889,0.01877109],"study_design_scores_gemma":[0.8975748,0.09930931,0.001274934,0.00002484117,0.0002748425,0.00004914688,0.00001102219,0.0003462784,0.0006517632,0.00004414279,0.0004299392,0.000008926869],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9878248,0.006734715,0.0006029982,0.0004906108,0.0005618906,0.002238165,0.0003360418,0.0001009749,0.001109857],"genre_scores_gemma":[0.9877071,0.004324787,0.001606524,0.0008985359,0.0007569895,0.002563753,0.0005933953,0.00001752488,0.001531349],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003708438,"threshold_uncertainty_score":0.01240599,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0226234012405232,"score_gpt":0.2774331805484901,"score_spread":0.2548097793079669,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}