{"id":"W2122597070","doi":"10.1172/jci46134","title":"PTHrP drives breast tumor initiation, progression, and metastasis in mice and is a potential therapy target","year":2011,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Bone health and treatments","field":"Medicine","cited_by":126,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; McGill University Health Centre","funders":"Canadian Institutes of Health Research; McGill University Health Centre; McGill University; Susan G. Komen for the Cure; U.S. Department of Defense","keywords":"Metastasis; Tumor progression; Parathyroid hormone-related protein; Cancer research; Cancer; Angiogenesis; Breast cancer; Medicine; Cyclin D1; Internal medicine; Biology; Cell cycle; Parathyroid hormone","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002944084,0.0004353618,0.0003367227,0.0007288773,0.000242914,0.0004915009,0.0003358837,0.0006262739,0.002471548],"category_scores_gemma":[0.0001231746,0.0003165661,0.0003180329,0.0003040701,0.0005763774,0.0003413761,0.0002784331,0.001686588,0.0005483294],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006137117,"about_ca_system_score_gemma":0.0004900355,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008864238,"about_ca_topic_score_gemma":0.001428915,"domain_scores_codex":[0.9996245,0.00006403858,0.00002307626,0.00007625729,0.0001331536,0.00007891384],"domain_scores_gemma":[0.9998358,0.00001742482,0.00005727059,0.00001773714,0.00001404183,0.00005768246],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003861278,0.0001339603,0.0001812515,0.00005029244,0.000007908304,0.0000692602,0.00002227098,0.00007197355,0.9949124,0.0005644299,0.0002523722,0.003347592],"study_design_scores_gemma":[0.0002498781,0.001954126,0.004171643,0.00003033754,0.0000525469,0.0007534411,0.00006406094,0.001959924,0.971876,0.0005608093,0.01831396,0.00001318407],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9562687,0.0120638,0.01510745,0.002312749,0.0002501547,0.000265479,0.002441348,0.001008887,0.01028155],"genre_scores_gemma":[0.9707611,0.005032823,0.007346363,0.0003683063,0.00006040527,0.0002520766,0.001175996,0.0001118021,0.01489107],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002471548,"threshold_uncertainty_score":0.008268118,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1042292031186872,"score_gpt":0.400679060061798,"score_spread":0.2964498569431108,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}