{"id":"W2122618364","doi":"10.1124/jpet.300.3.976","title":"Prevention of Antibody-Mediated Elimination of Ligand-Targeted Liposomes by Using Poly(Ethylene glycol)-Modified Lipids","year":2002,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Liposome; Hapten; Polyethylene glycol; Chemistry; PEG ratio; Biotin; Ethylene glycol; Immunogenicity; Bovine serum albumin; In vivo; Biochemistry; Antibody; Biology; Immunology; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003324784,0.0005064102,0.0003048753,0.0001859296,0.000133136,0.0003036304,0.0002787989,0.0004569599,0.0008503688],"category_scores_gemma":[0.0002337337,0.0002127023,0.0003306816,0.00009183279,0.0002126119,0.000343673,0.0002986077,0.0005942573,0.0003772513],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002408097,"about_ca_system_score_gemma":0.0001996724,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003710282,"about_ca_topic_score_gemma":0.0002948691,"domain_scores_codex":[0.9998446,0.00002964986,0.00001305095,0.0000202257,0.00003505244,0.00005747309],"domain_scores_gemma":[0.9998653,0.00003793696,0.0000377746,0.00001874346,0.00002254807,0.00001770653],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002943557,0.00003873802,0.00008392473,0.00005896042,0.00001070301,0.00005628678,0.00002318404,0.00009273821,0.9966587,0.0001898264,0.0000416048,0.002450887],"study_design_scores_gemma":[0.00001799914,0.0001167302,0.0001837811,0.000002526822,0.000007815879,0.00005797242,0.000002629173,0.0003508903,0.9988921,0.0000150788,0.0003510323,0.000001506103],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9855661,0.001431336,0.01161062,0.0001255202,0.00004394402,0.00008553539,0.00007590152,0.0001759423,0.000885095],"genre_scores_gemma":[0.9948751,0.0005427538,0.00269479,0.00006377931,0.000009441046,0.0000345056,0.0001072793,0.0000293983,0.001642793],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008503688,"threshold_uncertainty_score":0.00284481,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05603183188449895,"score_gpt":0.3960659818078742,"score_spread":0.3400341499233753,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}