{"id":"W2122626752","doi":"10.1158/1557-3265.pms14-a04","title":"Abstract A04: Changes in matrix metalloproteinase expression in SN-38 resistant colorectal cancer cells","year":2015,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"","keywords":"Matrix metalloproteinase; TIMP1; MMP1; Metastasis; Cancer research; Colorectal cancer; Cancer; Extracellular matrix; Cell culture; Biology; Cancer cell; Proteolytic enzymes; Pathology; Medicine; Cell biology; Internal medicine; Biochemistry; Enzyme; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001021248,0.0002347756,0.0002680946,0.0003600329,0.0001729384,0.000201004,0.0001504524,0.0002650089,0.00249948],"category_scores_gemma":[0.0001377324,0.0001039115,0.0002765853,0.0003149792,0.0001446527,0.00011571,0.00009762385,0.0003364952,0.0009098146],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002402069,"about_ca_system_score_gemma":0.0001688294,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002872767,"about_ca_topic_score_gemma":0.001402375,"domain_scores_codex":[0.9998055,0.00003243528,0.00002925303,0.00003510899,0.00006548434,0.00003238614],"domain_scores_gemma":[0.9998482,0.00003122511,0.00002312876,0.00002729666,0.00003430115,0.00003575534],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001631986,0.00005646994,0.0002661035,0.00002087717,0.000004441874,0.0001202142,0.00002215152,0.0000316489,0.9985108,0.00003998389,0.00005994872,0.0007042867],"study_design_scores_gemma":[0.00003204392,0.001975114,0.02440121,0.000004975018,0.00002119736,0.0009361406,0.0001283338,0.001423522,0.9672194,0.00004409777,0.003803839,0.00001009717],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952986,0.0007608236,0.0008233136,0.00007036499,0.00002801468,0.00004154124,0.001166642,0.00006026867,0.001750405],"genre_scores_gemma":[0.9892094,0.0004781772,0.001678181,0.00004340133,0.0000105986,0.00007986328,0.002726331,0.00001665395,0.005757312],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002872767,"threshold_uncertainty_score":0.008361638,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1531170009676041,"score_gpt":0.4788733247898995,"score_spread":0.3257563238222954,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}