{"id":"W2122641774","doi":"10.1161/circulationaha.105.600668","title":"Use and Misuse of Surrogate Outcomes in Arrhythmia Trials","year":2006,"lang":"en","type":"letter","venue":"Circulation","topic":"Health Systems, Economic Evaluations, Quality of Life","field":"Economics, Econometrics and Finance","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Medicine; Intensive care medicine; Surrogate endpoint; Cardiology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.2681311,0.0005829575,0.002677847,0.003273614,0.0009842822,0.006244061,0.002041687,0.01173075,0.003643073],"category_scores_gemma":[0.7493364,0.0007716215,0.00154469,0.005064619,0.004747247,0.005888517,0.002517816,0.01337887,0.002242214],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003659031,"about_ca_system_score_gemma":0.003472076,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006835649,"about_ca_topic_score_gemma":0.0008896785,"domain_scores_codex":[0.3859309,0.5437977,0.03385646,0.005079581,0.02973446,0.001600917],"domain_scores_gemma":[0.1138782,0.8064207,0.03900032,0.02158636,0.01567961,0.003434818],"domain_codex":"methods","domain_gemma":"methods","domain_candidate":"methods","domain_consensus":"methods","study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.007183757,0.0001556101,0.05586068,0.004560484,0.001428583,0.004224009,0.003376038,0.002354774,0.0006205434,0.1089756,0.3380593,0.4732007],"study_design_scores_gemma":[0.003207905,0.002559344,0.07252914,0.02455789,0.001533747,0.02404718,0.001592677,0.03743526,0.003880192,0.3080009,0.5201054,0.0005503815],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.02461719,0.05559231,0.02780674,0.8191887,0.009406824,0.0003530859,0.001692859,0.0002702192,0.06107216],"genre_scores_gemma":[0.6270041,0.02560835,0.02094615,0.2905816,0.02935868,0.00133045,0.0008074863,0.0002720928,0.004091105],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.7318689,"threshold_uncertainty_score":0.9025247,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.5411996732718042,"score_gpt":0.4428733761014161,"score_spread":0.09832629717038804,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}