{"id":"W2122648220","doi":"10.1093/toxsci/kfm051","title":"Tetrabromodiphenyl Ether (BDE 47) Evokes Estrogenicity and Calbindin-D9k Expression through an Estrogen Receptor-Mediated Pathway in the Uterus of Immature Rats","year":2007,"lang":"en","type":"article","venue":"Toxicological Sciences","topic":"Toxic Organic Pollutants Impact","field":"Environmental Science","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"Directorate for Education and Human Resources; Ministry of Education and Human Resources Development","keywords":"Polybrominated diphenyl ethers; Internal medicine; Endocrinology; Estrogen receptor; Endocrine system; Developmental toxicity; Endocrine disruptor; Estrogen; Chemistry; Receptor; Congener; Uterus; Ovariectomized rat; Biology; Hormone; Gestation; Medicine; Pregnancy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00012466,0.0005172091,0.0003877333,0.0005483548,0.0002198915,0.000181809,0.0001896433,0.0002432461,0.001289374],"category_scores_gemma":[0.0001569406,0.0003460317,0.000416967,0.0002180709,0.0005501655,0.0002781991,0.0002383585,0.0009553154,0.0002533348],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005040596,"about_ca_system_score_gemma":0.0004279911,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001764164,"about_ca_topic_score_gemma":0.004308205,"domain_scores_codex":[0.9998385,0.00001445543,0.00001424891,0.00003866465,0.00004233953,0.00005175348],"domain_scores_gemma":[0.9997869,0.00002298262,0.00007703571,0.00001741283,0.00002153227,0.00007416686],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007687304,0.000101488,0.0008333562,0.00003432044,0.000006464666,0.0001533584,0.00005384132,0.00004278076,0.9964059,0.00009564537,0.00003226017,0.001471868],"study_design_scores_gemma":[0.00007146509,0.002955491,0.02801087,0.00001313809,0.00004584915,0.0004052381,0.0002599724,0.0003555253,0.9661412,0.0001624164,0.001560876,0.00001784272],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997451,0.0008333859,0.0006501591,0.00008163954,0.00002419067,0.00001802123,0.0003219854,0.00003548,0.0005842065],"genre_scores_gemma":[0.9897276,0.001990118,0.002067421,0.0001095502,0.00001638287,0.00007595236,0.000654162,0.0000239947,0.005334896],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001764164,"threshold_uncertainty_score":0.00431335,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02879127758733879,"score_gpt":0.2899218375131886,"score_spread":0.2611305599258498,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}