{"id":"W2122655209","doi":"10.1038/nm1488","title":"Self-antigen tetramers discriminate between myelin autoantibodies to native or denatured protein","year":2007,"lang":"en","type":"article","venue":"Nature Medicine","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":412,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Hospital; Hospital for Sick Children; Montreal Neurological Institute and Hospital","funders":"National Institute of Neurological Disorders and Stroke; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases","keywords":"Autoantibody; Myelin oligodendrocyte glycoprotein; Tetramer; Experimental autoimmune encephalomyelitis; Antigen; Antibody; Myelin basic protein; Acute disseminated encephalomyelitis; Multiple sclerosis; Molecular biology; Radioimmunoassay; Epitope; Immunoprecipitation; Chemistry; Autoimmunity; Myelin; Immunology; Biology; Biochemistry; Neuroscience; Central nervous system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005452904,0.0004541326,0.0003351443,0.0005794518,0.0002063276,0.0005663993,0.000364268,0.0007678051,0.002570003],"category_scores_gemma":[0.0005457826,0.000302818,0.0003041913,0.0002127179,0.0002563469,0.0004389499,0.000411745,0.001461752,0.001192276],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003453579,"about_ca_system_score_gemma":0.0001416433,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001711583,"about_ca_topic_score_gemma":0.000170026,"domain_scores_codex":[0.9994527,0.000133918,0.00004357574,0.0001405797,0.00009188598,0.0001373633],"domain_scores_gemma":[0.9994718,0.0001705553,0.00008224535,0.00007298218,0.00006677878,0.000135676],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001908072,0.00006834708,0.0006462483,0.00001473803,0.000009495402,0.00002175381,0.00001773528,0.000031248,0.9975599,0.0001360919,0.00007556038,0.001228026],"study_design_scores_gemma":[0.0001642238,0.001129262,0.01707719,0.00002223834,0.00007187453,0.001068295,0.0001062524,0.004075746,0.9730887,0.0006377847,0.002539264,0.00001898425],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961711,0.0005412942,0.001892693,0.00007392669,0.00006997403,0.00002162407,0.00006629647,0.00004762699,0.00111558],"genre_scores_gemma":[0.9962013,0.0002654131,0.001413195,0.0002525734,0.00004957919,0.00002328395,0.0002603858,0.00003681465,0.001497375],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002570003,"threshold_uncertainty_score":0.008597493,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01290674965424015,"score_gpt":0.3109398488514713,"score_spread":0.2980330991972311,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}