{"id":"W2122660766","doi":"10.4161/epi.23400","title":"Hypoxia alters the epigenetic profile in cultured human placental trophoblasts","year":2013,"lang":"en","type":"article","venue":"Epigenetics","topic":"Pregnancy and preeclampsia studies","field":"Medicine","cited_by":86,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Child and Family Research Institute; Hospital for Sick Children; University of British Columbia","funders":"Canadian Institutes of Health Research; National Institutes of Health; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Foundation for Barnes-Jewish Hospital","keywords":"Cytotrophoblast; Biology; DNA methylation; Syncytiotrophoblasts; Syncytiotrophoblast; Epigenetics; Placenta; Oxygen tension; Methylation; Trophoblast; Placentation; CpG site; Molecular biology; Cell biology; Andrology; Fetus; Genetics; Gene expression; Gene; Oxygen; Pregnancy; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001002538,0.0002001885,0.0002663091,0.00005501822,0.0001688437,0.00002582938,0.0001756621,0.00009462212,0.0003874476],"category_scores_gemma":[0.00004735121,0.0001315077,0.00008831739,0.0001788215,0.0001783898,0.0000352274,0.00009520332,0.0002551193,0.0002924888],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005779548,"about_ca_system_score_gemma":0.00003702037,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001171005,"about_ca_topic_score_gemma":0.0001588563,"domain_scores_codex":[0.998707,0.00008500186,0.0003117305,0.0002627664,0.000234335,0.0003991943],"domain_scores_gemma":[0.9993277,0.00006125465,0.00006756774,0.0003948665,0.00004901565,0.00009958884],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002448966,0.001246328,0.5713969,0.0004870715,0.0005244723,0.0001603261,0.02014344,0.0002904217,0.3137794,0.0007362594,0.05737919,0.03361123],"study_design_scores_gemma":[0.001729932,0.0003906614,0.9592832,0.0002149766,0.00006562265,0.00002336419,0.0008529822,0.0002247397,0.03092202,0.000849557,0.00517724,0.0002656415],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9814945,0.005201852,0.00005015116,0.001562649,0.0002157268,0.001258027,0.000008117331,0.00004878366,0.01016012],"genre_scores_gemma":[0.9949867,0.0004398823,0.001307514,0.0004759342,0.0001546335,0.0002038854,0.00001937498,0.00002617204,0.002385931],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3878863,"threshold_uncertainty_score":0.5362727,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01705669384185034,"score_gpt":0.2614862998418012,"score_spread":0.2444296059999509,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}