{"id":"W2122660766","doi":"10.4161/epi.23400","title":"Hypoxia alters the epigenetic profile in cultured human placental trophoblasts","year":2013,"lang":"en","type":"article","venue":"Epigenetics","topic":"Pregnancy and preeclampsia studies","field":"Medicine","cited_by":86,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Child and Family Research Institute; Hospital for Sick Children; University of British Columbia","funders":"Canadian Institutes of Health Research; National Institutes of Health; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Foundation for Barnes-Jewish Hospital","keywords":"Cytotrophoblast; Biology; DNA methylation; Syncytiotrophoblasts; Syncytiotrophoblast; Epigenetics; Placenta; Oxygen tension; Methylation; Trophoblast; Placentation; CpG site; Molecular biology; Cell biology; Andrology; Fetus; Genetics; Gene expression; Gene; Oxygen; Pregnancy; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001366386,0.0001193531,0.0002012105,0.0001660831,0.0001328828,0.0001933249,0.0000922863,0.0001168581,0.0007874198],"category_scores_gemma":[0.0002131607,0.0001323019,0.0001494128,0.0001580424,0.0001139291,0.00008266237,0.0001955378,0.000163403,0.0002454607],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001458605,"about_ca_system_score_gemma":0.0001365385,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002276267,"about_ca_topic_score_gemma":0.002196753,"domain_scores_codex":[0.999864,0.00002768272,0.00001172179,0.00004373233,0.00003846593,0.00001436441],"domain_scores_gemma":[0.9999357,0.00002079676,0.00001085468,0.0000102775,0.0000147776,0.000007513977],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001490726,0.000006645215,0.002349411,0.00002436753,0.000007759002,0.00004559045,0.000110644,0.00005485079,0.9957122,0.0000208126,0.00003023342,0.001488464],"study_design_scores_gemma":[0.0000224496,0.0006046194,0.1318096,0.0000173865,0.0000667707,0.0005891642,0.000266206,0.001321533,0.8602186,0.0001319367,0.004935245,0.00001649103],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914899,0.00285758,0.003010319,0.00008342742,0.00002219589,0.00002879122,0.0009173788,0.00002827972,0.001561944],"genre_scores_gemma":[0.9924536,0.001190474,0.002040812,0.00008084888,0.00001108795,0.00005071925,0.001783613,0.00001267958,0.002375977],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002276267,"threshold_uncertainty_score":0.004525959,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01705669384185034,"score_gpt":0.2614862998418012,"score_spread":0.2444296059999509,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}