{"id":"W2122699281","doi":"10.1016/j.nbd.2010.11.003","title":"Depletion of Beclin-1 due to proteolytic cleavage by caspases in the Alzheimer's disease brain","year":2010,"lang":"en","type":"article","venue":"Neurobiology of Disease","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":158,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute on Aging; National Research Council Canada; University of California, Irvine; Directorate for Biological Sciences; Universiteit Gent; Vlaamse regering; National Institutes of Health; Fonds Wetenschappelijk Onderzoek","keywords":"Caspase; Cleavage (geology); Neuroscience; Alzheimer's disease; Disease; Cell biology; Apoptosis; Proteolytic enzymes; Chemistry; Biology; Biochemistry; Medicine; Programmed cell death; Pathology; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002838195,0.0002766006,0.0005164209,0.000608967,0.0003719555,0.0003655093,0.0002377441,0.000531516,0.001108863],"category_scores_gemma":[0.0002289588,0.0002955288,0.0002506963,0.0002298654,0.0006255828,0.0006675717,0.000251278,0.001140207,0.0002249406],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005777375,"about_ca_system_score_gemma":0.0004129884,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006605472,"about_ca_topic_score_gemma":0.0009827169,"domain_scores_codex":[0.9998754,0.00001779107,0.00002191772,0.00001945319,0.0000244003,0.00004090434],"domain_scores_gemma":[0.9998726,0.00001910865,0.00003778233,0.00001627773,0.00001707179,0.00003725281],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002090866,0.0001327606,0.0003889517,0.000130095,0.00003388197,0.0004935839,0.0000378149,0.00007440329,0.9926805,0.0006946309,0.0003148738,0.002927614],"study_design_scores_gemma":[0.0002380357,0.0007077443,0.01221982,0.00002100048,0.00007891468,0.004112118,0.0001234634,0.001152587,0.9781134,0.00141994,0.00179623,0.00001686022],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953441,0.002827833,0.0004501244,0.0003028576,0.00005871868,0.00001074575,0.0001395127,0.00002729774,0.0008388213],"genre_scores_gemma":[0.9957876,0.001565716,0.0009712771,0.00009558401,0.00001935514,0.00002274879,0.0002062503,0.00001087961,0.001320648],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001108863,"threshold_uncertainty_score":0.004191756,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0131741200400762,"score_gpt":0.2876300165707269,"score_spread":0.2744558965306507,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}