{"id":"W2122699281","doi":"10.1016/j.nbd.2010.11.003","title":"Depletion of Beclin-1 due to proteolytic cleavage by caspases in the Alzheimer's disease brain","year":2010,"lang":"en","type":"article","venue":"Neurobiology of Disease","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":158,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute on Aging; National Research Council Canada; University of California, Irvine; Directorate for Biological Sciences; Universiteit Gent; Vlaamse regering; National Institutes of Health; Fonds Wetenschappelijk Onderzoek","keywords":"Caspase; Cleavage (geology); Neuroscience; Alzheimer's disease; Disease; Cell biology; Apoptosis; Proteolytic enzymes; Chemistry; Biology; Biochemistry; Medicine; Programmed cell death; Pathology; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001975615,0.0001718012,0.0003170797,0.0001151761,0.0000394811,0.00000406733,0.00023969,0.00007448936,0.0001271049],"category_scores_gemma":[0.0004520707,0.0001237435,0.0001505257,0.0001956344,0.0002857555,0.00004135344,0.00004170876,0.0002415729,0.00002007342],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005433682,"about_ca_system_score_gemma":0.0001732096,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004360937,"about_ca_topic_score_gemma":0.00001848098,"domain_scores_codex":[0.9987357,0.0002029631,0.0003486753,0.0003151281,0.0001551753,0.0002423833],"domain_scores_gemma":[0.9985997,0.0002543864,0.0001250129,0.0006065437,0.00005250409,0.000361856],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.01859748,0.008224276,0.4581327,0.0006024083,0.0003465548,0.0007996678,0.0009268817,0.00003749898,0.4584665,0.002049068,0.04518282,0.006634152],"study_design_scores_gemma":[0.001794774,0.0006831362,0.9673862,0.00006079906,0.0002926046,0.000006769116,0.00004209745,0.00002574273,0.0277085,0.0005571354,0.001284992,0.0001572103],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905024,0.000351806,0.00001359651,0.007411066,0.0001327005,0.001200252,0.0002746626,0.00002647397,0.00008711218],"genre_scores_gemma":[0.9933679,0.00001457482,0.00003346094,0.006205509,0.0000808237,0.0001204136,0.0001223656,0.00002103746,0.00003394982],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5092535,"threshold_uncertainty_score":0.5046113,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0131741200400762,"score_gpt":0.2876300165707269,"score_spread":0.2744558965306507,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}